Tbio GUK1 Guanylate kinase

Protein Summary

Description

Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q16774
• B1ANH1

Gene Name

• GUK1

Ensembl ID

• ENST00000312726
• ENSP00000317659
• ENSG00000143774
• ENST00000366716
• ENSP00000355677
• ENST00000366718
• ENSP00000355679
• ENST00000366726
• ENSP00000355687
• ENST00000366728
• ENSP00000355689
• ENST00000366730
• ENSP00000355691
• ENST00000391865
• ENSP00000375738

Symbol

• GMK
• GMK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
molecular function	0.91
biological process	0.81
kinase perturbation	0.81
transcription factor	0.78

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleotide Kinase / Guanylate Kinase Family / Guanylate Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.01   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.01   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (223)

Explore Interacting Targets

1 – 10 of 223

• See Interactions on String-DB

TMEM97

Tchem

Novelty:  0.00597439

p_int:  0.993827229

p_ni:  0.006172771

Score:  0.535

Data Source:  BioPlex,STRINGDB

DPY19L2

Tbio

Family:  Enzyme

Novelty:  0.03435247

p_int:  0.972705414

p_ni:  0.027294586

Score:  0.68

Data Source:  BioPlex,STRINGDB

TTC19

Tbio

Novelty:  0.08251578

p_int:  0.965267022

p_ni:  0.034732976

p_wrong:  2e-9

Score:  0.255

Data Source:  BioPlex,STRINGDB

APRT

Tchem

Family:  Enzyme

Novelty:  0.00483077

Score:  0.967

Data Source:  STRINGDB

GMPS

Tbio

Family:  Enzyme

Novelty:  0.00611806

Score:  0.959

Data Source:  STRINGDB

ITPA

Tbio

Family:  Enzyme

Novelty:  0.00235169

Score:  0.955

Data Source:  STRINGDB

AK9

Tbio

Family:  Kinase

Novelty:  0.06306357

Score:  0.945

Data Source:  STRINGDB

NME3

Tbio

Family:  Kinase

Novelty:  0.05947052

Score:  0.931

Data Source:  STRINGDB

DGUOK

Tbio

Family:  Kinase

Novelty:  0.00897987

Score:  0.926

Data Source:  STRINGDB

GMPR2

Tbio

Family:  Enzyme

Novelty:  0.16707153

Score:  0.925

Data Source:  STRINGDB

Nearest Tclin Targets (18)

Explore Nearest Tclin Targets

Upstream (16)

Downstream (2)

1 – 5 of 16

RRM1

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE10A

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE3B

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE6C

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

PDE1C

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  2

1: Metabolic pathways

2: Purine metabolism

Pathways (10)

Reactome (5)

KEGG (2)

PathwayCommons (3)

Abacavir metabolism (R-HSA-2161541)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Abacavir metabolism	5 targets	R-HSA-2161541
Reactome	Abacavir transport and metabolism	10 targets	R-HSA-2161522
Reactome	Interconversion of nucleotide di- and triphosphates	30 targets	R-HSA-499943
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of nucleotides	100 targets	R-HSA-15869

Name	Explore in Pharos	Explore in Source
Abacavir metabolism	5 targets	R-HSA-2161541
Abacavir transport and metabolism	10 targets	R-HSA-2161522
Interconversion of nucleotide di- and triphosphates	30 targets	R-HSA-499943
Metabolism	2112 targets	R-HSA-1430728
Metabolism of nucleotides	100 targets	R-HSA-15869

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (2)

Components (1)

Processes (10)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
guanylate kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	2	1	0	1.2	46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
adolescent idiopathic scoliosis	EFO_0005423	0	1.2	46.1

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
ATP-binding
Complete proteome
Kinase
Nucleotide-binding
Reference proteome
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
adolescent idiopathic scoliosis

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	guanylate kinase 1	VGNC:10659	740432
Macaque	guanylate kinase 1		695272
Mouse	guanylate kinase 1	MGI:95871	14923
Rat	guanylate kinase 1	RGD:1309638	303179
Dog	guanylate kinase 1	VGNC:54767	475178

Species	Name	OMA	EggNOG	Inparanoid
Chimp	guanylate kinase 1
Macaque	guanylate kinase 1
Mouse	guanylate kinase 1
Rat	guanylate kinase 1
Dog	guanylate kinase 1

Publication Statistics

PubMed Score 178.01

PubMed score by year

Reset Zoom

PubTator Score 56.69

PubTator score by year

Reset Zoom

Patents

Patents by year

Reset Zoom

Related Publications

Text Mined References (12)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title