Tbio GUK1 Guanylate kinase

Protein Summary

Description

Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Uniprot Accession IDs

• Q16774
• B1ANH1

Gene Name

• GUK1

Ensembl ID

• ENST00000312726
• ENSP00000317659
• ENSG00000143774
• ENST00000366716
• ENSP00000355677
• ENST00000366718
• ENSP00000355679
• ENST00000366726
• ENSP00000355687
• ENST00000366728
• ENSP00000355689
• ENST00000366730
• ENSP00000355691
• ENST00000391865
• ENSP00000375738

Symbol

• GMK
• GMK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
molecular function	0.91
biological process	0.81
kinase perturbation	0.81
transcription factor	0.78

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleotide Kinase / Guanylate Kinase Family / Guanylate Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.24   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.24   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0