Protein Summary
Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
- ENST00000312726
- ENSP00000317659
- ENSG00000143774
- ENST00000366716
- ENSP00000355677
- ENST00000366718
- ENSP00000355679
- ENST00000366726
- ENSP00000355687
- ENST00000366728
- ENSP00000355689
- ENST00000366730
- ENSP00000355691
- ENST00000391865
- ENSP00000375738
- GMK
- GMK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
molecular function | 0.91 | ||
biological process | 0.81 | ||
kinase perturbation | 0.81 | ||
transcription factor | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.24 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.24 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0