Protein Summary
Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
- ENST00000312726
- ENSP00000317659
- ENSG00000143774
- ENST00000366716
- ENSP00000355677
- ENST00000366718
- ENSP00000355679
- ENST00000366726
- ENSP00000355687
- ENST00000366728
- ENSP00000355689
- ENST00000366730
- ENSP00000355691
- ENST00000391865
- ENSP00000375738
- GMK
- GMK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.97 | ||
molecular function | 0.91 | ||
biological process | 0.81 | ||
kinase perturbation | 0.81 | ||
transcription factor | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.01 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 178.01 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (223)
TMEM97
Novelty: 0.00597439
p_int: 0.993827229
p_ni: 0.006172771
Score: 0.535
Data Source: BioPlex,STRINGDB
DPY19L2
Family: Enzyme
Novelty: 0.03435247
p_int: 0.972705414
p_ni: 0.027294586
Score: 0.68
Data Source: BioPlex,STRINGDB
TTC19
Novelty: 0.08251578
p_int: 0.965267022
p_ni: 0.034732976
p_wrong: 2e-9
Score: 0.255
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (18)
Upstream (16)
Downstream (2)
1 – 5 of 16
Pathways (10)
Reactome (5)
KEGG (2)
PathwayCommons (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Abacavir metabolism | ||||
Reactome | Abacavir transport and metabolism | ||||
Reactome | Interconversion of nucleotide di- and triphosphates | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Abacavir metabolism | ||||
Abacavir transport and metabolism | ||||
Interconversion of nucleotide di- and triphosphates | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (1)
Processes (10)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
adolescent idiopathic scoliosis | 2 | 1 | 0 | 1.2 | 46.1 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
adolescent idiopathic scoliosis | 0 | 1.2 | 46.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | guanylate kinase 1 | VGNC:10659 | 740432 | |||||
Macaque | guanylate kinase 1 | 695272 | ||||||
Mouse | MGI:95871 | 14923 | ||||||
Rat | RGD:1309638 | 303179 | ||||||
Dog | guanylate kinase 1 | VGNC:54767 | 475178 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | guanylate kinase 1 | |||||
Macaque | guanylate kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | guanylate kinase 1 | |||||
Publication Statistics
PubMed Score 178.01
PubMed score by year
PubTator Score 56.69
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (12)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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