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Tbio
GUK1
Guanylate kinase

Protein Summary
Description
Essential for recycling GMP and indirectly, cGMP. The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312726
  • ENSP00000317659
  • ENSG00000143774
  • ENST00000366716
  • ENSP00000355677
  • ENST00000366718
  • ENSP00000355679
  • ENST00000366726
  • ENSP00000355687
  • ENST00000366728
  • ENSP00000355689
  • ENST00000366730
  • ENSP00000355691
  • ENST00000391865
  • ENSP00000375738

Symbol
  • GMK
  • GMK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
molecular function
0.91
biological process
0.81
kinase perturbation
0.81
transcription factor
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.01   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.01   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (223)
TMEM97
Tchem
Novelty:  0.00597439
p_int:  0.993827229
p_ni:  0.006172771
Score:  0.535
Data Source:  BioPlex,STRINGDB
DPY19L2
Tbio
Family:  Enzyme
Novelty:  0.03435247
p_int:  0.972705414
p_ni:  0.027294586
Score:  0.68
Data Source:  BioPlex,STRINGDB
TTC19
Tbio
Novelty:  0.08251578
p_int:  0.965267022
p_ni:  0.034732976
p_wrong:  2e-9
Score:  0.255
Data Source:  BioPlex,STRINGDB
APRT
Tchem
Family:  Enzyme
Novelty:  0.00483077
Score:  0.967
Data Source:  STRINGDB
GMPS
Tbio
Family:  Enzyme
Novelty:  0.00611806
Score:  0.959
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.955
Data Source:  STRINGDB
AK9
Tbio
Family:  Kinase
Novelty:  0.06306357
Score:  0.945
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.931
Data Source:  STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
Score:  0.926
Data Source:  STRINGDB
GMPR2
Tbio
Family:  Enzyme
Novelty:  0.16707153
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
1 – 5 of 16
RRM1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE10A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE3B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (10)
Abacavir metabolism (R-HSA-2161541)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abacavir metabolism
Reactome
Abacavir transport and metabolism
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Abacavir metabolism
Abacavir transport and metabolism
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
2
1
0
1.2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.2
46.1
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate kinase 1
VGNC:10659
740432
Macaque
guanylate kinase 1
695272
Mouse
MGI:95871
14923
Rat
RGD:1309638
303179
Dog
guanylate kinase 1
VGNC:54767
475178
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate kinase 1
Macaque
guanylate kinase 1
Mouse
Rat
Dog
guanylate kinase 1
Publication Statistics
PubMed Score 178.01
PubMed score by year
PubTator Score 56.69
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title