You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KYAT1
Kynurenine--oxoglutarate transaminase 1

Protein Summary
Description
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302586
  • ENSP00000302227
  • ENSG00000171097
  • ENST00000320665
  • ENSP00000317342

Symbol
  • CCBL1
  • GTK
  • KAT1
  • KATI
  • CCBL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.35   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.35   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
29.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kynurenine aminotransferase 1
VGNC:13905
473069
Macaque
kynurenine aminotransferase 1
717142
Mouse
MGI:1917516
70266
Rat
RGD:1306912
311844
Dog
kynurenine aminotransferase 1
VGNC:42553
491310
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kynurenine aminotransferase 1
Macaque
kynurenine aminotransferase 1
Mouse
Rat
Dog
kynurenine aminotransferase 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16773-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Glutamate and glutamine metabolism (R-HSA-8964539)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate and glutamine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Phenylalanine and tyrosine metabolism
Reactome
Phenylalanine metabolism
Name
Explore in Pharos
Explore in Source
Glutamate and glutamine metabolism
Metabolism
Metabolism of amino acids and derivatives
Phenylalanine and tyrosine metabolism
Phenylalanine metabolism
Gene Ontology Terms (16)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
ZNF318
Tbio
Novelty: 0.03072403
p_int: 0.986097524
p_ni: 0.013902353
p_wrong: 1.23e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
YEATS2
Tbio
Novelty: 0.17584498
p_int: 0.911852921
p_ni: 0.088147079
Score: 0.719
Data Source: BioPlex,STRINGDB
ZZZ3
Tdark
Family: TF
Novelty: 0.23862921
p_int: 0.822165516
p_ni: 0.177834483
Score: 0.702
Data Source: BioPlex,STRINGDB
MBIP
Tbio
Novelty: 0.05807454
p_int: 0.809101212
p_ni: 0.187361064
p_wrong: 0.003537724
Score: 0.719
Data Source: BioPlex,STRINGDB
AADAT
Tchem
Family: Enzyme
Novelty: 0.00678753
Score: 0.99
Data Source: STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.988
Data Source: STRINGDB
KMO
Tchem
Family: Enzyme
Novelty: 0.01469543
Score: 0.984
Data Source: STRINGDB
AFMID
Tbio
Family: Enzyme
Novelty: 0.02027656
Score: 0.959
Data Source: STRINGDB
CTH
Tchem
Family: Enzyme
Novelty: 0.0017155
Score: 0.939
Data Source: STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.922
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.35

PubMed score by year
PubTator Score  95.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer