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Tbio
GSTA3
Glutathione S-transferase A3

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)-pregnene-3,20-dione, precursors to testosterone and progesterone, respectively. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211122
  • ENSP00000211122
  • ENSG00000174156

Symbol
  • GTA3
  • GSTA3-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.95
disease perturbation
0.9
PubMedID
0.82
transcription factor perturbation
0.8
gene perturbation
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.33   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.33   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
GSTA1
Tchem
Family:  Enzyme
Novelty:  0.00308319
p_int:  1
Score:  0.872
Data Source:  BioPlex,STRINGDB
GSTA2
Tbio
Family:  Enzyme
Novelty:  0.01131783
p_int:  0.999999997
p_ni:  3e-9
Score:  0.875
Data Source:  BioPlex,STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.902
Data Source:  STRINGDB
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
Score:  0.839
Data Source:  STRINGDB
GSTO1
Tchem
Family:  Enzyme
Novelty:  0.00800915
Score:  0.831
Data Source:  STRINGDB
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
Score:  0.827
Data Source:  STRINGDB
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
Score:  0.822
Data Source:  STRINGDB
GSTO2
Tbio
Family:  Enzyme
Novelty:  0.01836256
Score:  0.819
Data Source:  STRINGDB
MGST1
Tbio
Family:  Enzyme
Novelty:  0.00681882
Score:  0.803
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.802
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (19)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
2
2
91.5
platelet count
3
3
3
89.9
1
1
0
1.1
78.5
testosterone measurement
2
2
2
42.2
platelet crit
1
1
1
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
2
91.5
platelet count
3
89.9
0
1.1
78.5
testosterone measurement
2
42.2
platelet crit
1
42.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95856
14859
Rat
RGD:11504935
108348061
Dog
glutathione S-transferase A2
474938
Horse
glutathione S-transferase alpha 1
100056332
Cow
glutathione S-transferase alpha 2
281805
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
glutathione S-transferase A2
Horse
glutathione S-transferase alpha 1
Cow
glutathione S-transferase alpha 2
Publication Statistics
PubMed Score 51.33
PubMed score by year
PubTator Score 24.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title