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Tbio
UBE2S
Ubiquitin-conjugating enzyme E2 S

Protein Summary
Description
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linke ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264552
  • ENSP00000264552
  • ENSG00000108106

Symbol
  • E2EPF
  • EPF5
  • E2EPF
  • E2-EPF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
interacting protein
0.91
gene perturbation
0.85
transcription factor binding site profile
0.83
small molecule perturbation
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 493   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.85   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 493   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Protein-Protein Interactions (439)
1 – 10 of 439
LRRC4C
Tbio
Novelty: 0.00535393
p_int: 0.971352205
p_ni: 0.02864568
p_wrong: 0.000002115
Score: 0.224
Data Source: BioPlex,STRINGDB
YAF2
Tbio
Novelty: 0.14775726
p_int: 0.961345714
p_ni: 0.038654281
p_wrong: 5e-9
Score: 0.196
Data Source: BioPlex,STRINGDB
C11orf74
Tbio
Novelty: 0.01457372
p_int: 0.824965791
p_ni: 0.175034209
Score: 0.29
Data Source: BioPlex,STRINGDB
CDC27
Tbio
Novelty: 0.00956925
Score: 0.999
Data Source: STRINGDB
CDC23
Tbio
Novelty: 0.02675154
Score: 0.999
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00161137
Score: 0.999
Data Source: STRINGDB
FZR1
Tbio
Novelty: 0.01409033
Score: 0.999
Data Source: STRINGDB
ANAPC11
Tbio
Family: Enzyme
Novelty: 0.04056134
Score: 0.999
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00237728
Score: 0.999
Data Source: STRINGDB
ANAPC2
Tbio
Family: Enzyme
Novelty: 0.25398893
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  165.85

PubMed score by year
PubTator Score  26.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer