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Tbio
DGKD
Diacylglycerol kinase delta

Protein Summary
Description
May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264057
  • ENSP00000264057
  • ENSG00000077044
  • ENST00000409813
  • ENSP00000386455
  • ENST00000628356
  • ENSP00000487220
  • ENSG00000280873
  • ENST00000628527
  • ENSP00000487423

Symbol
  • KIAA0145
  • dgkd-2
  • DGKdelta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.99
molecular function
0.98
metabolite
0.85
cell type or tissue
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.18   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.18   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
3
1.1
95
4
2
3
1.1
95
bilirubin measurement
2
2
2
88.2
bilirubin measurement
2
2
2
88.2
calcium measurement
2
2
2
85.1
Items per page:
1 – 5 of 25
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
95
3
1.1
95
bilirubin measurement
2
88.2
bilirubin measurement
2
88.2
calcium measurement
2
85.1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (26)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
IntAct
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (76)
1 – 10 of 76
DGKG
Tbio
Family: Enzyme
Novelty: 0.03666646
p_int: 0.999999274
p_ni: 1.5e-8
p_wrong: 7.1e-7
Score: 0.194
Data Source: BioPlex,STRINGDB
FEZ1
Tbio
Novelty: 0.02695814
p_int: 0.999992389
p_ni: 7.6e-8
p_wrong: 0.000007534
Score: 0.309
Data Source: BioPlex,STRINGDB
PLCB2
Tbio
Family: Enzyme
Novelty: 0.00571285
Score: 0.778
Data Source: STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.737
Data Source: STRINGDB
CDS2
Tbio
Family: Enzyme
Novelty: 0.13210626
Score: 0.731
Data Source: STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.08094799
Score: 0.73
Data Source: STRINGDB
PLCD4
Tbio
Family: Enzyme
Novelty: 0.07014141
Score: 0.723
Data Source: STRINGDB
AGPAT5
Tbio
Family: Enzyme
Novelty: 0.23785857
Score: 0.72
Data Source: STRINGDB
PLCZ1
Tbio
Family: Enzyme
Novelty: 0.0059826
Score: 0.716
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.715
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.18

PubMed score by year
PubTator Score  12.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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