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Tclin
UGCG
Ceramide glucosyltransferase

Protein Summary
Description
Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". This gene encodes an enzyme that catalyzes the first glycosylation step in the biosynthesis of glycosphingolipids, which are membrane components containing lipid and sugar moieties. The product of this reaction is glucosylceramide, which is the core structure of many glycosphingolipids. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374279
  • ENSP00000363397
  • ENSG00000148154

Symbol
  • GCS
  • GLCT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
transcription factor binding site profile
0.8
small molecule perturbation
0.75
PubMedID
0.73
cell type or tissue
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.69   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 167.69   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 109
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
miglustat
chemical structure image
eliglustat
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
90.5
mean corpuscular hemoglobin concentration
1
1
1
74.2
red blood cell density measurement
1
1
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
90.5
mean corpuscular hemoglobin concentration
1
74.2
red blood cell density measurement
1
73.5
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose ceramide glucosyltransferase
VGNC:13988
464660
Macaque
UDP-glucose ceramide glucosyltransferase
707875
Mouse
MGI:1332243
22234
Rat
RGD:621870
83626
Dog
UDP-glucose ceramide glucosyltransferase
VGNC:48116
481666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose ceramide glucosyltransferase
Macaque
UDP-glucose ceramide glucosyltransferase
Mouse
Rat
Dog
UDP-glucose ceramide glucosyltransferase
Pathways (9)
Glycosphingolipid metabolism (R-HSA-1660662)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosphingolipid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Glycosphingolipid metabolism
Metabolism
Metabolism of lipids
Sphingolipid metabolism
Protein-Protein Interactions (149)
1 – 10 of 149
C16orf58
Tdark
Novelty: 0.34461652
p_int: 0.999741058
p_ni: 0.000258934
p_wrong: 8e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
p_int: 0.999670654
p_ni: 0.000329339
p_wrong: 7e-9
Data Source: BioPlex
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.999624967
p_ni: 0.000375022
p_wrong: 1.1e-8
Data Source: BioPlex
CD83
Tbio
Novelty: 0.00138653
p_int: 0.999624967
p_ni: 0.000375022
p_wrong: 1.1e-8
Data Source: BioPlex
SLC20A1
Tbio
Family: Transporter
Novelty: 0.01123373
p_int: 0.99956665
p_ni: 0.000373153
p_wrong: 0.000060197
Score: 0.444
Data Source: BioPlex,STRINGDB
TSPAN3
Tbio
Novelty: 0.06362133
p_int: 0.999551637
p_ni: 0.000322717
p_wrong: 0.000125647
Score: 0.523
Data Source: BioPlex,STRINGDB
TMEM231
Tbio
Novelty: 0.17100188
p_int: 0.999541978
p_ni: 0.000164848
p_wrong: 0.000293174
Score: 0.524
Data Source: BioPlex,STRINGDB
PTGIR
Tclin
Family: GPCR
Novelty: 0.0091906
p_int: 0.998647558
p_ni: 0.000961367
p_wrong: 0.000391075
Data Source: BioPlex
HEPACAM2
Tbio
Novelty: 0.19192547
p_int: 0.862954937
p_ni: 0.004032116
p_wrong: 0.133012947
Score: 0.516
Data Source: BioPlex,STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
p_int: 0.841298611
p_ni: 0.000384914
p_wrong: 0.158316475
Score: 0.738
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  167.69

PubMed score by year
PubTator Score  256.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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