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Tbio
ATP2B3
Plasma membrane calcium-transporting ATPase 3

Protein Summary
Description
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 3. Alternatively splic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263519
  • ENSP00000263519
  • ENSG00000067842
  • ENST00000349466
  • ENSP00000343886
  • ENST00000359149
  • ENSP00000352062
  • ENST00000370186
  • ENSP00000359205
  • ENST00000393842
  • ENSP00000377425

Symbol
  • CLA2
  • OPCA
  • PMCA3
  • SCAX1
  • CFAP39
  • PMCA3a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
interacting protein
0.69
cell type or tissue
0.68
microRNA
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.63   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 66   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.63   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1347353
320707
Rat
RGD:621304
29599
Dog
ATPase plasma membrane Ca2+ transporting 3
VGNC:38258
492238
Horse
ATPase plasma membrane Ca2+ transporting 3
VGNC:15655
100057711
Cow
ATPase plasma membrane Ca2+ transporting 3
VGNC:26295
504353
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ATPase plasma membrane Ca2+ transporting 3
Horse
ATPase plasma membrane Ca2+ transporting 3
Cow
ATPase plasma membrane Ca2+ transporting 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16720-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Gene Ontology Terms (19)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO-UCL
Inferred from Direct Assay (IDA)
SynGO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (213)
1 – 10 of 213
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.999999896
p_ni: 1.04e-7
Score: 0.578
Data Source: BioPlex,STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
p_int: 0.999998316
p_ni: 0.000001684
Score: 0.372
Data Source: BioPlex,STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.999990096
p_ni: 0.000009904
Score: 0.531
Data Source: BioPlex,STRINGDB
RANBP6
Tdark
Novelty: 0.75714796
p_int: 0.99978019
p_ni: 0.00021981
Score: 0.164
Data Source: BioPlex,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.999773419
p_ni: 0.000226581
Data Source: BioPlex
LILRB4
Tbio
Novelty: 0.01443658
p_int: 0.999718286
p_ni: 0.000281713
Score: 0.207
Data Source: BioPlex,STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
p_int: 0.999578057
p_ni: 0.000421943
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999342348
p_ni: 0.000657652
Data Source: BioPlex
GALNT6
Tbio
Family: Enzyme
Novelty: 0.04627605
p_int: 0.999327683
p_ni: 0.000672316
Data Source: BioPlex
IPPK
Tbio
Family: Enzyme
Novelty: 0.02169701
p_int: 0.999184633
p_ni: 0.000815367
Data Source: BioPlex
Publication Statistics
PubMed Score  109.63

PubMed score by year
PubTator Score  52.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer