Protein Classes
Protein Summary
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
- ENST00000264170
- ENSP00000264170
- ENSG00000115919
- ENST00000375773
- ENSP00000364928
- ENST00000409512
- ENSP00000386731
- KYNUU
- VCRL2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
small molecule perturbation | 0.93 | ||
virus perturbation | 0.88 | ||
PubMedID | 0.87 | ||
trait | 0.86 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.25 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 39.25 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (15)
Reactome (3)
KEGG (2)
PathwayCommons (4)
UniProt (2)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Tryptophan catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Tryptophan catabolism | ||||
Gene Ontology Terms (18)
Functions (4)
Components (3)
Processes (11)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-UniRule | |||
Protein-Protein Interactions (105)
1 – 10 of 105
KMO
Family: Enzyme
Novelty: 0.00558444
Score: 0.999
Data Source: STRINGDB
HAAO
Family: Enzyme
Novelty: 0.02398057
Score: 0.998
Data Source: STRINGDB
TDO2
Family: Enzyme
Novelty: 0.00123905
Score: 0.996
Data Source: STRINGDB
KYAT1
Family: Enzyme
Novelty: 0.01429382
Score: 0.988
Data Source: STRINGDB
AADAT
Family: Enzyme
Novelty: 0.0054217
Score: 0.982
Data Source: STRINGDB
KYAT3
Family: Enzyme
Novelty: 0.09558489
Score: 0.982
Data Source: STRINGDB
AFMID
Family: Enzyme
Novelty: 0.02056908
Score: 0.973
Data Source: STRINGDB
IDO1
Family: Enzyme
Novelty: 0.00188077
Score: 0.972
Data Source: STRINGDB
IDO2
Family: Enzyme
Novelty: 0.01019298
Score: 0.97
Data Source: STRINGDB
ACMSD
Family: Enzyme
Novelty: 0.01978706
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score 39.25
PubMed score by year
PubTator Score 22.22
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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