NDUFA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]
- ENST00000355749
- ENSP00000347988
- ENSG00000128609
- ENST00000471770
- ENSP00000417142
- B13
- NUFM
- UQOR13
- CI-13kB
- CI-13KD-B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.94 | ||
cellular component | 0.87 | ||
histone modification site profile | 0.78 | ||
virus perturbation | 0.76 | ||
tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.55 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 157 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 49.55 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 157 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (0)
Protein-Protein Interactions (176)
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.995254049
p_ni: 0.004745951
Score: 0.99
Data Source: BioPlex,STRINGDB
NDUFS3
Family: Enzyme
Novelty: 0.01968313
p_int: 0.959238723
p_ni: 0.040761277
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF4
Family: Enzyme
Novelty: 0.10799507
p_int: 0.898095226
p_ni: 0.101904775
Score: 0.969
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (18)
Reactome (5)
KEGG (8)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 1 | 2 | 58.4 | |||||
reticulocyte count | 2 | 1 | 2 | 52.7 | |||||
platelet count | 1 | 1 | 1 | 13.6 | |||||
platelet crit | 1 | 1 | 1 | 9.9 | |||||
HbA1c measurement | 1 | 1 | 1 | 0.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 58.4 | |||||
reticulocyte count | 2 | 52.7 | |||||
platelet count | 1 | 13.6 | |||||
platelet crit | 1 | 9.9 | |||||
HbA1c measurement | 1 | 0.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A5 | VGNC:14053 | 463686 | |||||
Macaque | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 695066 | ||||||
Macaque | NADH:ubiquinone oxidoreductase subunit A5 | 100430178 | ||||||
Mouse | MGI:1915452 | 68202 | ||||||
Rat | RGD:3155 | 25488 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A5 | |||||
Macaque | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | |||||
Macaque | NADH:ubiquinone oxidoreductase subunit A5 | |||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 49.55
PubMed score by year
PubTator Score 183.42
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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