NDUFA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]
- ENST00000355749
- ENSP00000347988
- ENSG00000128609
- ENST00000471770
- ENSP00000417142
- B13
- NUFM
- UQOR13
- CI-13kB
- CI-13KD-B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.94 | ||
cellular component | 0.87 | ||
histone modification site profile | 0.78 | ||
virus perturbation | 0.76 | ||
tissue | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.04 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 157 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 76.04 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 157 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1