You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355749
  • ENSP00000347988
  • ENSG00000128609
  • ENST00000471770
  • ENSP00000417142

Symbol
  • B13
  • NUFM
  • UQOR13
  • CI-13kB
  • CI-13KD-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
cellular component
0.87
histone modification site profile
0.78
virus perturbation
0.76
tissue
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (176)
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.995254049
p_ni:  0.004745951
Score:  0.99
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.959238723
p_ni:  0.040761277
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFAF4
Tclin
Family:  Enzyme
Novelty:  0.10799507
p_int:  0.898095226
p_ni:  0.101904775
Score:  0.969
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
Score:  0.999
Data Source:  STRINGDB
NDUFB3
Tclin
Family:  Enzyme
Novelty:  0.13020753
Score:  0.999
Data Source:  STRINGDB
NDUFA6
Tclin
Family:  Enzyme
Novelty:  0.01236094
Score:  0.999
Data Source:  STRINGDB
NDUFV2
Tclin
Family:  Enzyme
Novelty:  0.02240263
Score:  0.999
Data Source:  STRINGDB
NDUFS5
Tclin
Family:  Enzyme
Novelty:  0.13274675
Score:  0.999
Data Source:  STRINGDB
NDUFB8
Tclin
Family:  Enzyme
Novelty:  0.019021
Score:  0.999
Data Source:  STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
1
2
58.4
reticulocyte count
2
1
2
52.7
platelet count
1
1
1
13.6
platelet crit
1
1
1
9.9
HbA1c measurement
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
58.4
reticulocyte count
2
52.7
platelet count
1
13.6
platelet crit
1
9.9
HbA1c measurement
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A5
VGNC:14053
463686
Macaque
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
695066
Macaque
NADH:ubiquinone oxidoreductase subunit A5
100430178
Mouse
MGI:1915452
68202
Rat
RGD:3155
25488
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A5
Macaque
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Macaque
NADH:ubiquinone oxidoreductase subunit A5
Mouse
Rat
Publication Statistics
PubMed Score 49.55
PubMed score by year
PubTator Score 183.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title