NDUFA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
Protein Classes
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This nuclear gene encodes a conserved protein that comprises the B13 subunit of complex I of the mitochondrial respiratory chain. The encoded protein localizes to the inner mitochondrial membrane, where it is thought to aid in the transfer of electrons from NADH to ubiquinone. Alternative splicing results in multiple transcript variants. There are numerous pseudogenes of this gene on chromosomes 1, 3, 6, 8, 9, 11, 12, and 16. [provided by RefSeq, Apr 2014]
- ENST00000355749
- ENSP00000347988
- ENSG00000128609
- ENST00000471770
- ENSP00000417142
- B13
- NUFM
- UQOR13
- CI-13kB
- CI-13KD-B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.94 | ||
cellular component | 0.87 | ||
histone modification site profile | 0.78 | ||
virus perturbation | 0.76 | ||
tissue | 0.71 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.47 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 157 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.47 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 157 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A5 | VGNC:14053 | 463686 | |||||
Macaque | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | 695066 | ||||||
Macaque | NADH:ubiquinone oxidoreductase subunit A5 | 100430178 | ||||||
Mouse | MGI:1915452 | 68202 | ||||||
Rat | RGD:3155 | 25488 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A5 | |||||
Macaque | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | |||||
Macaque | NADH:ubiquinone oxidoreductase subunit A5 | |||||
Mouse | ||||||
Rat | ||||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (18)
Reactome (5)
KEGG (8)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (176)
1 – 10 of 176
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.995254049
p_ni: 0.004745951
Score: 0.99
Data Source: BioPlex,STRINGDB
NDUFS3
Family: Enzyme
Novelty: 0.01968313
p_int: 0.959238723
p_ni: 0.040761277
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF4
Family: Enzyme
Novelty: 0.10799507
p_int: 0.898095226
p_ni: 0.101904775
Score: 0.969
Data Source: BioPlex,STRINGDB
NDUFB3
Family: Enzyme
Novelty: 0.13020753
Score: 0.999
Data Source: STRINGDB
NDUFS7
Family: Enzyme
Novelty: 0.01562198
Score: 0.999
Data Source: STRINGDB
NDUFA6
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFV2
Family: Enzyme
Novelty: 0.02240263
Score: 0.999
Data Source: STRINGDB
NDUFS5
Family: Enzyme
Novelty: 0.13274675
Score: 0.999
Data Source: STRINGDB
NDUFB8
Family: Enzyme
Novelty: 0.019021
Score: 0.999
Data Source: STRINGDB
NDUFAB1
Novelty: 0.00190242
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 48.47
PubMed score by year
PubTator Score 183.42
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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