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Tbio
DECR1
2,4-dienoyl-CoA reductase, mitochondrial

Protein Summary
Description
Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220764
  • ENSP00000220764
  • ENSG00000104325
  • ENST00000522161
  • ENSP00000429779

Symbol
  • DECR
  • SDR18C1
  • DECR
  • NADPH
  • SDR18C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.95
interacting protein
0.93
transcription factor perturbation
0.88
cellular component
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.81   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.81   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (614)
FAM118B
Tdark
Novelty:  0.48168976
p_int:  0.99940519
p_ni:  0.00059481
Score:  0.188
Data Source:  BioPlex,STRINGDB
AFAP1L1
Tbio
Novelty:  0.2636613
p_int:  0.99776765
p_ni:  0.00223235
Data Source:  BioPlex
PTTG1
Tbio
Novelty:  0.00304349
p_int:  0.974853682
p_ni:  0.025146318
Score:  0.894
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.962858147
p_ni:  0.037141853
Score:  0.209
Data Source:  BioPlex,STRINGDB
NDUFA10
Tclin
Family:  Enzyme
Novelty:  0.06260343
p_int:  0.885332257
p_ni:  0.114667743
Score:  0.242
Data Source:  BioPlex,STRINGDB
CYBB
Tchem
Family:  IC
Novelty:  0.00054866
Score:  0.968
Data Source:  STRINGDB
NOX4
Tchem
Family:  Enzyme
Novelty:  0.0009803
Score:  0.943
Data Source:  STRINGDB
NOX1
Tchem
Family:  Enzyme
Novelty:  0.0016839
Score:  0.939
Data Source:  STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.935
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Reactome
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
72.9
smoking status measurement
2
2
2
67.2
lymphocyte percentage of leukocytes
1
1
1
27.5
substance abuse
1
1
1
13.4
antisocial behaviour measurement
1
1
1
13.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
72.9
smoking status measurement
2
67.2
lymphocyte percentage of leukocytes
1
27.5
substance abuse
1
13.4
antisocial behaviour measurement
1
13.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
2,4-dienoyl-CoA reductase 1
VGNC:14565
736777
Macaque
2,4-dienoyl-CoA reductase 1
696035
Mouse
MGI:1914710
67460
Rat
RGD:70999
117543
Dog
2,4-dienoyl-CoA reductase 1
VGNC:39871
477938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
2,4-dienoyl-CoA reductase 1
Macaque
2,4-dienoyl-CoA reductase 1
Mouse
Rat
Dog
2,4-dienoyl-CoA reductase 1
Publication Statistics
PubMed Score 74.81
PubMed score by year
PubTator Score 570.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title