Protein Summary
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
- ENST00000330436
- ENSP00000332679
- ENSG00000197838
- CPAD
- CYP2A
- CYPIIA13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.93 | ||
molecular function | 0.73 | ||
protein domain | 0.58 | ||
pathway | 0.57 | ||
cell line | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.45 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 142.45 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (68)
Nearest Tclin Targets (5)
Upstream (2)
Downstream (3)
1 – 2 of 2
Pathways (22)
Reactome (8)
KEGG (2)
PathwayCommons (2)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Aflatoxin activation and detoxification | ||||
Reactome | Biological oxidations | ||||
Reactome | CYP2E1 reactions | ||||
Reactome | Cytochrome P450 - arranged by substrate type | ||||
Reactome | Fatty acids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Aflatoxin activation and detoxification | ||||
Biological oxidations | ||||
CYP2E1 reactions | ||||
Cytochrome P450 - arranged by substrate type | ||||
Fatty acids | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (8)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
DDT metabolite measurement | 2 | 3 | 3 | 92.9 | |||||
1 | 1 | 0 | 1.2 | 46.5 | |||||
gestational serum measurement | 2 | 1 | 2 | 45.7 | |||||
organochlorine pesticide measurement | 1 | 1 | 1 | 45.7 | |||||
polybrominated biphenyl measurement | 1 | 1 | 1 | 21.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
DDT metabolite measurement | 3 | 92.9 | |||||
0 | 1.2 | 46.5 | |||||
gestational serum measurement | 2 | 45.7 | |||||
organochlorine pesticide measurement | 1 | 45.7 | |||||
polybrominated biphenyl measurement | 1 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 142.45
PubMed score by year
PubTator Score 87.15
PubTator score by year
Related Publications
Text Mined References (54)
GeneRif Annotations (37)
Items per page:
0 of 0
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