Tbio CYP2A13 Cytochrome P450 2A13

Protein Summary

Description

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16696
• Q53YR8
• Q6R569
• Q6R570
• Q9H2X2

Gene Name

• CYP2A13

Ensembl ID

• ENST00000330436
• ENSP00000332679
• ENSG00000197838

Symbol

• CPAD
• CYP2A
• CYPIIA13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
molecular function	0.73
protein domain	0.58
pathway	0.57
cell line	0.55

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.08   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.08   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (8)

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (22)

Reactome (8)

KEGG (2)

PathwayCommons (2)

WikiPathways (10)

Aflatoxin activation and detoxification (R-HSA-5423646)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Aflatoxin activation and detoxification	20 targets	R-HSA-5423646
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	CYP2E1 reactions	11 targets	R-HSA-211999
Reactome	Cytochrome P450 - arranged by substrate type	65 targets	R-HSA-211897
Reactome	Fatty acids	15 targets	R-HSA-211935

Name	Explore in Pharos	Explore in Source
Aflatoxin activation and detoxification	20 targets	R-HSA-5423646
Biological oxidations	221 targets	R-HSA-211859
CYP2E1 reactions	11 targets	R-HSA-211999
Cytochrome P450 - arranged by substrate type	65 targets	R-HSA-211897
Fatty acids	15 targets	R-HSA-211935

Gene Ontology Terms (18)

Functions (8)

Components (4)

Processes (6)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
heme binding	Inferred from Direct Assay (IDA)	UniProtKB
arachidonic acid epoxygenase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
steroid hydroxylase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
coumarin 7-hydroxylase activity	Traceable Author Statement (TAS)	Reactome
monooxygenase activity	Traceable Author Statement (TAS)	Reactome
aromatase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
iron ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

CYP2A7

Tbio

Novelty: 0.01218328

p_int: 1

Score: 0.783

Data Source: BioPlex,STRINGDB

EPHX1

Tchem

Family: Enzyme

Novelty: 0.00220169

Score: 0.944

Data Source: STRINGDB

CYP3A4

Tclin

Family: Enzyme

Novelty: 0.00015515

Score: 0.94

Data Source: STRINGDB

CYP3A5

Tclin

Family: Enzyme

Novelty: 0.00105607

Score: 0.936

Data Source: STRINGDB

CYP1A2

Tchem

Novelty: 0.00034756

Score: 0.924

Data Source: STRINGDB

CYP1A1

Tchem

Novelty: 0.0002404

Score: 0.922

Data Source: STRINGDB

AKR1C1

Tchem

Family: Enzyme

Novelty: 0.0043847

Score: 0.919

Data Source: STRINGDB

HSD11B1

Tclin

Family: Enzyme

Novelty: 0.00105097

Score: 0.917

Data Source: STRINGDB

CYP2D6

Tclin

Family: Enzyme

Novelty: 0.00021853

Score: 0.914

Data Source: STRINGDB

AKR1C2

Tchem

Family: Enzyme

Novelty: 0.00134228

Score: 0.911

Data Source: STRINGDB

Publication Statistics

PubMed Score  142.08

PubMed score by year

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PubTator Score  87.15

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase

MGI Phenotype Find Similar Targets

homeostasis/metabolism phenotype