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Tchem
CYP2A13
Cytochrome P450 2A13

Protein Summary
Description
Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330436
  • ENSP00000332679
  • ENSG00000197838

Symbol
  • CPAD
  • CYP2A
  • CYPIIA13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
molecular function
0.73
protein domain
0.58
pathway
0.57
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.45   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.45   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (68)
CYP2A7
Tbio
Novelty:  0.01218328
p_int:  1
Score:  0.783
Data Source:  BioPlex,STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.944
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.94
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.936
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.924
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.922
Data Source:  STRINGDB
AKR1C1
Tchem
Family:  Enzyme
Novelty:  0.0043847
Score:  0.919
Data Source:  STRINGDB
HSD11B1
Tclin
Family:  Enzyme
Novelty:  0.00105097
Score:  0.917
Data Source:  STRINGDB
CYP2D6
Tclin
Family:  Enzyme
Novelty:  0.00021853
Score:  0.914
Data Source:  STRINGDB
AKR1C2
Tchem
Family:  Enzyme
Novelty:  0.00134228
Score:  0.911
Data Source:  STRINGDB
Pathways (22)
Aflatoxin activation and detoxification (R-HSA-5423646)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
CYP2E1 reactions
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Fatty acids
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
CYP2E1 reactions
Cytochrome P450 - arranged by substrate type
Fatty acids
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DDT metabolite measurement
2
3
3
92.9
1
1
0
1.2
46.5
gestational serum measurement
2
1
2
45.7
organochlorine pesticide measurement
1
1
1
45.7
polybrominated biphenyl measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DDT metabolite measurement
3
92.9
0
1.2
46.5
gestational serum measurement
2
45.7
organochlorine pesticide measurement
1
45.7
polybrominated biphenyl measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 142.45
PubMed score by year
PubTator Score 87.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title