Tbio HIST3H3 Histone H3.1t

Protein Summary

Description

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• Q16695
• B2R5K3
• Q6FGU4
• H3/t

Gene Name

• HIST3H3

Ensembl ID

• ENST00000366696
• ENSP00000355657
• ENSG00000168148
• ENST00000644869
• ENSP00000494070
• ENSG00000285435

Symbol

• H3FT
• H3t
• H3.4
• H3/g
• H3FT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
cell type or tissue	0.85
chemical	0.8
tissue sample	0.8
biological term	0.75

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: < 5)

Gene RIFs: 71   (req: <= 3)

Antibodies: 1794   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.27   (req: >= 5)

Gene RIFs: 71   (req: > 3)

Antibodies: 1794   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Structure (7 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16695-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (425)

Reactome (39)

KEGG (3)

PathwayCommons (5)

WikiPathways (378)

Base Excision Repair (R-HSA-73884)

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Items per page:

5

1 – 5 of 39

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Base Excision Repair	72 targets	R-HSA-73884
Reactome	Base-Excision Repair, AP Site Formation	44 targets	R-HSA-73929
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Base Excision Repair	72 targets	R-HSA-73884
Base-Excision Repair, AP Site Formation	44 targets	R-HSA-73929
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Gene Ontology Terms (13)

Functions (2)

Components (6)

Processes (5)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
nucleosomal DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (313)

Explore Interacting Targets

1 – 10 of 313

• See Interactions on String-DB

HIST1H2BJ

Tbio

Novelty: 0.14308844

Score: 0.995

Data Source: STRINGDB

PYGO1

Tdark

Family: Epigenetic

Novelty: 0.18099753

Score: 0.994

Data Source: STRINGDB

BCL9

Tbio

Novelty: 0.01853613

Score: 0.994

Data Source: STRINGDB

KDM4A

Tchem

Family: Epigenetic

Novelty: 0.00643043

Score: 0.992

Data Source: Reactome,STRINGDB

H3F3A

Tbio

Novelty: 0.00508186

Score: 0.989

Data Source: STRINGDB

HIST2H2BE

Tbio

Novelty: 0.00024381

Score: 0.984

Data Source: STRINGDB

HIST3H2A

Tbio

Novelty: 0.34036249

Score: 0.982

Data Source: STRINGDB

HIST1H3A

Tbio

Novelty: 0.00991842

Score: 0.981

Data Source: STRINGDB

H2AFJ

Tbio

Novelty: 0.34726304

Score: 0.976

Data Source: STRINGDB

UBA52

Tbio

Novelty: 0.01637744

Score: 0.975

Data Source: STRINGDB

Publication Statistics

PubMed Score  17.27

PubMed score by year

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PubTator Score  16.31

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
ADP-ribosylation
Chromosome
Citrullination
Complete proteome
DNA-binding
Hydroxylation
Methylation
Nucleosome core