Protein Summary
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 fa ...more
- ENST00000366696
- ENSP00000355657
- ENSG00000168148
- ENST00000644869
- ENSP00000494070
- ENSG00000285435
- H3FT
- H3t
- H3.4
- H3/g
- H3FT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.96 | ||
cell type or tissue | 0.85 | ||
chemical | 0.8 | ||
tissue sample | 0.8 | ||
biological term | 0.75 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.27 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 1794 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.27 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 1794 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 1 | 1 | 35 | |||||
Progressive supranuclear palsy | 1 | 1 | 0 | 5.5 | 33.1 | ||||
glomerular filtration rate | 2 | 1 | 2 | 28.1 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 1 | 1 | 0 | 15744.7 | 11.3 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 35 | |||||
Progressive supranuclear palsy | 0 | 5.5 | 33.1 | ||||
glomerular filtration rate | 2 | 28.1 | |||||
soluble triggering receptor expressed on myeloid cells 2 measurement | 0 | 15744.7 | 11.3 | ||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (425)
Reactome (39)
KEGG (3)
PathwayCommons (5)
WikiPathways (378)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 39
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Base Excision Repair | ||||
Reactome | Base-Excision Repair, AP Site Formation | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Base Excision Repair | ||||
Base-Excision Repair, AP Site Formation | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Gene Ontology Terms (13)
Functions (2)
Components (6)
Processes (5)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (313)
1 – 10 of 313
HIST1H2BJ
Novelty: 0.14308844
Score: 0.995
Data Source: STRINGDB
PYGO1
Family: Epigenetic
Novelty: 0.18099753
Score: 0.994
Data Source: STRINGDB
BCL9
Novelty: 0.01853613
Score: 0.994
Data Source: STRINGDB
KDM4A
Family: Epigenetic
Novelty: 0.00643043
Score: 0.992
Data Source: Reactome,STRINGDB
H3F3A
Novelty: 0.00508186
Score: 0.989
Data Source: STRINGDB
HIST2H2BE
Novelty: 0.00024381
Score: 0.984
Data Source: STRINGDB
HIST3H2A
Novelty: 0.34036249
Score: 0.982
Data Source: STRINGDB
HIST1H3A
Novelty: 0.00991842
Score: 0.981
Data Source: STRINGDB
H2AFJ
Novelty: 0.34726304
Score: 0.976
Data Source: STRINGDB
UBA52
Novelty: 0.01637744
Score: 0.975
Data Source: STRINGDB
Publication Statistics
PubMed Score 18.27
PubMed score by year
PubTator Score 16.31
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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