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Tbio
HIST3H3
Histone H3.1t

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 fa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366696
  • ENSP00000355657
  • ENSG00000168148
  • ENST00000644869
  • ENSP00000494070
  • ENSG00000285435

Symbol
  • H3FT
  • H3t
  • H3.4
  • H3/g
  • H3FT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
cell type or tissue
0.85
chemical
0.8
tissue sample
0.8
biological term
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.27   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 1794   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.27   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 1794   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
1
35
Progressive supranuclear palsy
1
1
0
5.5
33.1
glomerular filtration rate
2
1
2
28.1
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
11.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
35
Progressive supranuclear palsy
0
5.5
33.1
glomerular filtration rate
2
28.1
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
11.3
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16695-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (425)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (313)
1 – 10 of 313
HIST1H2BJ
Tbio
Novelty:  0.14308844
Score:  0.995
Data Source:  STRINGDB
PYGO1
Tdark
Family:  Epigenetic
Novelty:  0.18099753
Score:  0.994
Data Source:  STRINGDB
BCL9
Tbio
Novelty:  0.01853613
Score:  0.994
Data Source:  STRINGDB
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
Score:  0.992
Data Source:  Reactome,STRINGDB
H3F3A
Tbio
Novelty:  0.00508186
Score:  0.989
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.984
Data Source:  STRINGDB
HIST3H2A
Tbio
Novelty:  0.34036249
Score:  0.982
Data Source:  STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
Score:  0.981
Data Source:  STRINGDB
H2AFJ
Tbio
Novelty:  0.34726304
Score:  0.976
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.975
Data Source:  STRINGDB
Publication Statistics
PubMed Score  18.27

PubMed score by year
PubTator Score  16.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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