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Tchem
DUSP5
Dual specificity protein phosphatase 5

Protein Summary
Description
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369583
  • ENSP00000358596
  • ENSG00000138166

Symbol
  • VH3
  • DUSP
  • HVH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.97
protein domain
0.97
transcription factor binding site profile
0.94
small molecule perturbation
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.73   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 574.73   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (70)
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.99
Data Source:  Reactome,STRINGDB
MAPK3
Tchem
Family:  Kinase
Novelty:  0.00012969
Score:  0.986
Data Source:  Reactome,STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.87
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.826
Data Source:  STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
Score:  0.804
Data Source:  STRINGDB
DUSP11
Tbio
Family:  Enzyme
Novelty:  0.01548269
Score:  0.804
Data Source:  STRINGDB
MAPK10
Tchem
Family:  Kinase
Novelty:  0.00420573
Score:  0.766
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.764
Data Source:  STRINGDB
SNRK
Tchem
Family:  Kinase
Novelty:  0.00707197
Score:  0.763
Data Source:  STRINGDB
MAPK12
Tchem
Family:  Kinase
Novelty:  0.00835017
Score:  0.763
Data Source:  STRINGDB
Pathways (16)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
Immune System
Reactome
MAPK family signaling cascades
Reactome
MAPK1/MAPK3 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
FLT3 Signaling
Immune System
MAPK family signaling cascades
MAPK1/MAPK3 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
75.1
bone density
1
1
1
23.7
1
1
0
1.4
22.5
serum non-albumin protein measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
75.1
bone density
1
23.7
0
1.4
22.5
serum non-albumin protein measurement
1
16.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685183
240672
Rat
RGD:620854
171109
Dog
dual specificity phosphatase 5
VGNC:40134
486884
Horse
dual specificity phosphatase 5
VGNC:17357
100068966
Cow
dual specificity phosphatase 5
VGNC:28261
507061
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
dual specificity phosphatase 5
Horse
dual specificity phosphatase 5
Cow
dual specificity phosphatase 5
Publication Statistics
PubMed Score 574.73
PubMed score by year
PubTator Score 46.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title