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Tchem
CYP1B1
Cytochrome P450 1B1

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta-estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610745
  • ENSP00000478561
  • ENSG00000138061
  • ENST00000614273
  • ENSP00000483678

Symbol
  • CP1B
  • ASGD6
  • GLC3A
  • CYPIB1
  • P4501B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
gene perturbation
1
PubMedID
1
biological process
0.99
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1296.92   (req: < 5)
Gene RIFs: 354   (req: <= 3)
Antibodies: 377   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1296.92   (req: >= 5)
Gene RIFs: 354   (req: > 3)
Antibodies: 377   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 41
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 311
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (136)
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.972
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.97
Data Source:  STRINGDB
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
Score:  0.954
Data Source:  STRINGDB
AHR
Tclin
Family:  TF
Novelty:  0.37065152
Score:  0.943
Data Source:  STRINGDB
HSD17B6
Tbio
Family:  Enzyme
Novelty:  0.01428594
Score:  0.943
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.935
Data Source:  STRINGDB
HSD17B2
Tchem
Family:  Enzyme
Novelty:  0.00960865
Score:  0.935
Data Source:  STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
Score:  0.933
Data Source:  STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
Score:  0.933
Data Source:  STRINGDB
SULT2A1
Tbio
Family:  Enzyme
Novelty:  0.00475549
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets (11)
Explore Nearest Tclin Targets
1 – 5 of 10
DDC
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  1
TPH1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  1
HSD3B2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP19A1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
CYP17A1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (56)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Defective CYP1B1 causes Glaucoma
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Cytochrome P450 - arranged by substrate type
Defective CYP1B1 causes Glaucoma
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
92.3
2
1
1
1.1
69.7
frontal fibrosing alopecia
1
1
0
1.6
66.6
eosinophil count
3
3
3
57.5
keratinocyte carcinoma
1
1
0
1.1
55.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
92.3
1
1.1
69.7
frontal fibrosing alopecia
0
1.6
66.6
eosinophil count
3
57.5
keratinocyte carcinoma
0
1.1
55.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 1, subfamily B, polypeptide 1
710385
Mouse
MGI:88590
13078
Rat
RGD:2460
25426
Dog
cytochrome P450 family 1 subfamily B member 1
VGNC:50334
483038
Horse
cytochrome P450 family 1 subfamily B member 1
VGNC:50559
100070088
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 1, subfamily B, polypeptide 1
Mouse
Rat
Dog
cytochrome P450 family 1 subfamily B member 1
Horse
cytochrome P450 family 1 subfamily B member 1
Publication Statistics
PubMed Score 1296.92
PubMed score by year
PubTator Score 1080.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title