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Tbio
FOXD1
Forkhead box protein D1

Protein Summary
Description
Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902). This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615637
  • ENSP00000481581
  • ENSG00000251493

Symbol
  • FKHL8
  • FREAC4
  • FKHL8
  • FREAC4
  • FREAC-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
gene perturbation
0.86
biological process
0.85
molecular function
0.79
transcription factor binding site profile
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.41   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.41   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16676-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Preimplantation Embryo
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Preimplantation Embryo
Endoderm Differentiation
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (19)
1 – 10 of 19
SIX2
Tbio
Family: TF
Novelty: 0.01046481
Score: 0.772
Data Source: STRINGDB
PAX2
Tbio
Family: TF
Novelty: 0.00160808
Score: 0.618
Data Source: STRINGDB
EYA1
Tbio
Novelty: 0.00585286
Score: 0.595
Data Source: STRINGDB
WT1
Tbio
Family: TF
Novelty: 0.00034353
Score: 0.591
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.584
Data Source: STRINGDB
CITED1
Tbio
Novelty: 0.01956689
Score: 0.566
Data Source: STRINGDB
SALL1
Tbio
Family: TF
Novelty: 0.00366705
Score: 0.562
Data Source: STRINGDB
HOXB7
Tbio
Family: TF
Novelty: 0.00765378
Score: 0.561
Data Source: STRINGDB
WNT9B
Tbio
Novelty: 0.01146843
Score: 0.542
Data Source: STRINGDB
SIX1
Tbio
Family: TF
Novelty: 0.00415613
Score: 0.525
Data Source: STRINGDB
Publication Statistics
PubMed Score  76.41

PubMed score by year
PubTator Score  26.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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