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Tbio
MIA
Melanoma-derived growth regulatory protein

Protein Summary
Description
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263369
  • ENSP00000263369
  • ENSG00000261857
  • ENST00000594436
  • ENSP00000470129
  • ENST00000597784
  • ENSP00000469499

Symbol
  • CD-RAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
biological term
0.57
tissue
0.52
disease
0.49
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.95   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.95   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (14)
S100B
Tchem
Novelty:  0.00031007
Score:  0.632
Data Source:  STRINGDB
COL11A2
Tbio
Novelty:  0.00923441
Score:  0.568
Data Source:  STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.544
Data Source:  STRINGDB
KCNJ2
Tchem
Family:  IC
Novelty:  0.00290395
Score:  0.527
Data Source:  STRINGDB
CDH7
Tbio
Novelty:  0.03451354
Score:  0.516
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.486
Data Source:  STRINGDB
STOX2
Tbio
Novelty:  0.48153003
Score:  0.481
Data Source:  STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
Score:  0.48
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.474
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.47
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
Find Similar Targets
Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
WikiPathways
Neural Crest Differentiation
Name
Explore in Pharos
Explore in Source
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Neural Crest Differentiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (37)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nicotine metabolite ratio
3
11
12
99.8
cigarettes per day measurement
6
8
12
99.1
hematocrit
3
7
9
98.6
hemoglobin measurement
3
6
9
98.3
smoking cessation
2
4
5
95.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
nicotine metabolite ratio
12
99.8
cigarettes per day measurement
12
99.1
hematocrit
9
98.6
hemoglobin measurement
9
98.3
smoking cessation
5
95.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanoma inhibitory activity
456048
Macaque
melanoma inhibitory activity
702844
Mouse
MGI:5439452
Rat
RGD:620883
81510
Horse
melanoma inhibitory activity
100064799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanoma inhibitory activity
Macaque
melanoma inhibitory activity
Mouse
Rat
Horse
melanoma inhibitory activity
Publication Statistics
PubMed Score 100.95
PubMed score by year
PubTator Score 120.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title