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Tbio
IFI16
Gamma-interferon-inducible protein 16

Protein Summary
Description
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295809
  • ENSP00000295809
  • ENSG00000163565
  • ENST00000359709
  • ENSP00000352740
  • ENST00000368131
  • ENSP00000357113
  • ENST00000368132
  • ENSP00000357114
  • ENST00000448393
  • ENSP00000404325

Symbol
  • IFNGIP1
  • PYHIN2
  • IFNGIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
biological process
0.99
kinase perturbation
0.99
disease perturbation
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.58   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.58   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
3
2
5
95.6
granulocyte count
1
1
1
84
hemoglobin measurement
1
1
1
83.6
erythrocyte count
1
1
1
83.6
hematocrit
1
1
1
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
5
95.6
granulocyte count
1
84
hemoglobin measurement
1
83.6
erythrocyte count
1
83.6
hematocrit
1
83.6
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon gamma inducible protein 16
VGNC:8913
457424
Macaque
interferon gamma inducible protein 16
719253
Mouse
MGI:101847
226695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon gamma inducible protein 16
Macaque
interferon gamma inducible protein 16
Mouse
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16666-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (91)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
IRF3-mediated induction of type I IFN
Reactome
Immune System
Reactome
Innate Immune System
Reactome
STING mediated induction of host immune responses
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Immune System
Innate Immune System
STING mediated induction of host immune responses
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (87)
1 – 10 of 87
TMEM173
Tchem
Novelty:  0.0070581
Score:  0.978
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.966
Data Source:  STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.965
Data Source:  STRINGDB
DDX41
Tbio
Family:  Enzyme
Novelty:  0.01658581
Score:  0.959
Data Source:  STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.944
Data Source:  STRINGDB
CGAS
Tchem
Family:  Enzyme
Novelty:  0.00239778
Score:  0.89
Data Source:  STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.842
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.838
Data Source:  STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.833
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.779
Data Source:  STRINGDB
Publication Statistics
PubMed Score  172.58

PubMed score by year
PubTator Score  131.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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