IFI16
Gamma-interferon-inducible protein 16
Protein Summary
Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral ...more
- ENST00000295809
- ENSP00000295809
- ENSG00000163565
- ENST00000359709
- ENSP00000352740
- ENST00000368131
- ENSP00000357113
- ENST00000368132
- ENSP00000357114
- ENST00000448393
- ENSP00000404325
- IFNGIP1
- PYHIN2
- IFNGIP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
biological process | 0.99 | ||
kinase perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.58 (req: < 5)
Gene RIFs: 106 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 172.58 (req: >= 5)
Gene RIFs: 106 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 32
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (87)
Nearest Tclin Targets
Pathways (91)
Reactome (5)
KEGG (1)
PathwayCommons (1)
WikiPathways (84)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytosolic sensors of pathogen-associated DNA | ||||
Reactome | IRF3-mediated induction of type I IFN | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | STING mediated induction of host immune responses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytosolic sensors of pathogen-associated DNA | ||||
IRF3-mediated induction of type I IFN | ||||
Immune System | ||||
Innate Immune System | ||||
STING mediated induction of host immune responses | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (6)
Components (6)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
leukocyte count | 3 | 2 | 5 | 95.6 | |||||
granulocyte count | 1 | 1 | 1 | 84 | |||||
erythrocyte count | 1 | 1 | 1 | 83.6 | |||||
hemoglobin measurement | 1 | 1 | 1 | 83.6 | |||||
hematocrit | 1 | 1 | 1 | 83.6 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
leukocyte count | 5 | 95.6 | |||||
granulocyte count | 1 | 84 | |||||
erythrocyte count | 1 | 83.6 | |||||
hemoglobin measurement | 1 | 83.6 | |||||
hematocrit | 1 | 83.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interferon gamma inducible protein 16 | VGNC:8913 | 457424 | |||||
Macaque | interferon gamma inducible protein 16 | 719253 | ||||||
Mouse | MGI:101847 | 226695 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interferon gamma inducible protein 16 | |||||
Macaque | interferon gamma inducible protein 16 | |||||
Mouse | ||||||
Publication Statistics
PubMed Score 172.58
PubMed score by year
PubTator Score 131.50
PubTator score by year
Related Publications
Text Mined References (136)
GeneRif Annotations (106)
Items per page:
0 of 0
PMID | Year | Title |
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