Tbio IFI16 Gamma-interferon-inducible protein 16

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Gamma-interferon-inducible Protein 16

DTO Classes

Protein / Transcription Factor / Gamma-interferon-inducible Protein 16

Protein Summary

Description

Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

Uniprot Accession IDs

• Q16666
• B4DJT8
• H3BLV7
• Q59GX0
• Q5T3W7
• Q5T3W8
• Q5T3X0
• Q5T3X1
• Q5T3X2
• Q8N9E5
• Q8NEQ7
• Q96AJ5
• Q9UH78
• Ifi-16

Gene Name

• IFI16

Ensembl ID

• ENST00000295809
• ENSP00000295809
• ENSG00000163565
• ENST00000359709
• ENSP00000352740
• ENST00000368131
• ENSP00000357113
• ENST00000368132
• ENSP00000357114
• ENST00000448393
• ENSP00000404325

Symbol

• IFNGIP1
• PYHIN2
• IFNGIP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
virus perturbation	1
biological process	0.99
kinase perturbation	0.99
disease perturbation	0.97

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.58   (req: < 5)

Gene RIFs: 106   (req: <= 3)

Antibodies: 306   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.58   (req: >= 5)

Gene RIFs: 106   (req: > 3)

Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (9)

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1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	3	2	5		95.6
granulocyte count	EFO_0007987	1	1	1		84
hemoglobin measurement	EFO_0004509	1	1	1		83.6
erythrocyte count	EFO_0004305	1	1	1		83.6
hematocrit	EFO_0004348	1	1	1		83.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
leukocyte count	EFO_0004308	5		95.6
granulocyte count	EFO_0007987	1		84
hemoglobin measurement	EFO_0004509	1		83.6
erythrocyte count	EFO_0004305	1		83.6
hematocrit	EFO_0004348	1		83.6

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Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interferon gamma inducible protein 16	VGNC:8913	457424
Macaque	interferon gamma inducible protein 16		719253
Mouse	interferon activated gene 205	MGI:101847	226695

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interferon gamma inducible protein 16
Macaque	interferon gamma inducible protein 16
Mouse	interferon activated gene 205

Protein Structure (6 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16666-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (91)

Reactome (5)

KEGG (1)

PathwayCommons (1)

WikiPathways (84)

Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
Reactome	IRF3-mediated induction of type I IFN	13 targets	R-HSA-3270619
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	STING mediated induction of host immune responses	16 targets	R-HSA-1834941

Name	Explore in Pharos	Explore in Source
Cytosolic sensors of pathogen-associated DNA	64 targets	R-HSA-1834949
IRF3-mediated induction of type I IFN	13 targets	R-HSA-3270619
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
STING mediated induction of host immune responses	16 targets	R-HSA-1834941

Gene Ontology Terms (38)

Functions (6)

Components (6)

Processes (26)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
double-stranded DNA binding	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
transcription factor binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Protein-Protein Interactions (87)

Explore Interacting Targets

1 – 10 of 87

• See Interactions on String-DB

TMEM173

Tchem

Novelty:  0.0070581

Score:  0.978

Data Source:  STRINGDB

IRF3

Tbio

Family:  TF

Novelty:  0.00099474

Score:  0.966

Data Source:  STRINGDB

TBK1

Tchem

Family:  Kinase

Novelty:  0.00194753

Score:  0.965

Data Source:  STRINGDB

DDX41

Tbio

Family:  Enzyme

Novelty:  0.01658581

Score:  0.959

Data Source:  STRINGDB

PYCARD

Tbio

Novelty:  0.00719985

Score:  0.944

Data Source:  STRINGDB

CGAS

Tchem

Family:  Enzyme

Novelty:  0.00239778

Score:  0.89

Data Source:  STRINGDB

AIM2

Tbio

Novelty:  0.00360474

Score:  0.842

Data Source:  STRINGDB

CASP1

Tchem

Family:  Enzyme

Novelty:  0.00034643

Score:  0.838

Data Source:  STRINGDB

DDX58

Tbio

Family:  Enzyme

Novelty:  0.00080099

Score:  0.833

Data Source:  STRINGDB

TP53

Tchem

Family:  TF

Novelty:  0.00001907

Score:  0.779

Data Source:  STRINGDB

Publication Statistics

PubMed Score  172.58

PubMed score by year

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PubTator Score  131.5

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Activator
Alternative splicing
Apoptosis
Autophagy
Complete proteome
Cytoplasm
DNA-binding
Immunity

GWAS Trait Find Similar Targets

No Header	No Header
CCL2 measurement
erythrocyte count
granulocyte count
hematocrit
hemoglobin measurement
leukocyte count
lymphocyte percentage of leukocytes
neutrophil percentage of leukocytes
psoriasis

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
hematopoietic system phenotype
immune system phenotype