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Tchem
HIF1A
Hypoxia-inducible factor 1-alpha

Protein Summary
Description
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323441
  • ENSP00000323326
  • ENSG00000100644
  • ENST00000337138
  • ENSP00000338018
  • ENST00000539097
  • ENSP00000437955

Symbol
  • BHLHE78
  • MOP1
  • PASD8
  • HIF1
  • MOP1
  • PASD8
  • HIF-1A
  • bHLHe78
  • HIF-1alpha
  • HIF1-ALPHA
  • HIF-1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
disease perturbation
0.97
molecular function
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10731.15   (req: < 5)
Gene RIFs: 2638   (req: <= 3)
Antibodies: 2061   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10731.15   (req: >= 5)
Gene RIFs: 2638   (req: > 3)
Antibodies: 2061   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 97
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma exacerbation measurement
1
1
0
1.6
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma exacerbation measurement
0
1.6
1.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 1 subunit alpha
VGNC:8202
746195
Macaque
hypoxia inducible factor 1 alpha subunit
704678
Mouse
MGI:106918
15251
Rat
RGD:61928
29560
Dog
hypoxia inducible factor 1 subunit alpha
VGNC:41686
480348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypoxia inducible factor 1 subunit alpha
Macaque
hypoxia inducible factor 1 alpha subunit
Mouse
Rat
Dog
hypoxia inducible factor 1 subunit alpha
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16665-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
Cellular response to hypoxia (R-HSA-1234174)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to hypoxia
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Circadian Clock
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Cellular response to hypoxia
Cellular responses to external stimuli
Cellular responses to stress
Circadian Clock
Cytokine Signaling in Immune system
Gene Ontology Terms (108)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (432)
1 – 10 of 432
MYH6
Tbio
Novelty:  0.00058671
p_int:  1
Score:  0.45
Data Source:  BioPlex,STRINGDB
MYH2
Tbio
Novelty:  0.00365878
p_int:  0.999999992
p_ni:  7e-9
p_wrong:  1e-9
Score:  0.307
Data Source:  BioPlex,STRINGDB
MYH1
Tbio
Novelty:  0.00472973
p_int:  0.999999942
p_ni:  5.7e-8
p_wrong:  1e-9
Score:  0.246
Data Source:  BioPlex,STRINGDB
MYH3
Tbio
Novelty:  0.00544794
p_int:  0.999999922
p_ni:  7.7e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999999872
p_ni:  1.28e-7
Score:  0.331
Data Source:  BioPlex,STRINGDB
MYH4
Tbio
Novelty:  0.00556982
p_int:  0.999999711
p_ni:  2.88e-7
p_wrong:  1e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
p_int:  0.999997789
p_ni:  0.000002211
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ARNT2
Tbio
Family:  TF
Novelty:  0.01485424
p_int:  0.999792323
p_ni:  0.00008864
p_wrong:  0.000119038
Score:  0.974
Data Source:  BioPlex,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.996703717
p_ni:  0.000825344
p_wrong:  0.002470939
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MYL1
Tbio
Novelty:  0.00360262
p_int:  0.978943081
p_ni:  0.000001495
p_wrong:  0.021055424
Score:  0.347
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10731.15

PubMed score by year
PubTator Score  6984.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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