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Tchem
HIF1A
Hypoxia-inducible factor 1-alpha

Protein Summary
Description
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Activation requires recruitment of transcriptional coactivators such as CREBBP and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323441
  • ENSP00000323326
  • ENSG00000100644
  • ENST00000337138
  • ENSP00000338018
  • ENST00000539097
  • ENSP00000437955

Symbol
  • BHLHE78
  • MOP1
  • PASD8
  • HIF1
  • MOP1
  • PASD8
  • HIF-1A
  • bHLHe78
  • HIF-1alpha
  • HIF1-ALPHA
  • HIF-1-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
disease perturbation
0.97
molecular function
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12164.25   (req: < 5)
Gene RIFs: 2638   (req: <= 3)
Antibodies: 2061   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12164.25   (req: >= 5)
Gene RIFs: 2638   (req: > 3)
Antibodies: 2061   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 97
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 90
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2