Tbio CCL15 C-C motif chemokine 15

Protein Summary

Description

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q16663
• B2RU34
• E1P651
• Q9UM74

Gene Name

• CCL15

Ensembl ID

• ENST00000614050
• ENSP00000477788
• ENSG00000275528
• ENST00000617897
• ENSP00000484078
• ENSG00000275718

Symbol

• MIP5
• NCC3
• SCYA15
• LKN1
• NCC3
• SY15
• HCC-2
• LKN-1
• MIP-5
• NCC-3
• SCYL3
• MIP-1D
• MRP-2B
• SCYA15
• HMRP-2B
• MIP-1 delta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.57
molecular function	0.56
cell line	0.53
PubMedID	0.51
transcription factor	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / C-c Motif Chemokine 15

DTO Classes

Protein / Signaling / Chemokine / C-c Motif Chemokine 15

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.33   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 385   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.33   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0