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Tbio
CCL15
C-C motif chemokine 15

Protein Summary
Description
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000614050
  • ENSP00000477788
  • ENSG00000275528
  • ENST00000617897
  • ENSP00000484078
  • ENSG00000275718

Symbol
  • MIP5
  • NCC3
  • SCYA15
  • LKN1
  • NCC3
  • SY15
  • HCC-2
  • LKN-1
  • MIP-5
  • NCC-3
  • SCYL3
  • MIP-1D
  • MRP-2B
  • SCYA15
  • HMRP-2B
  • MIP-1 delta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.57
molecular function
0.56
cell line
0.53
PubMedID
0.51
transcription factor
0.5


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.94   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 385   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.94   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 385   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
1
1
1
73
protein measurement
1
1
1
73
fetal genotype effect measurement
1
1
1
73
fetal genotype effect measurement
1
1
1
73
CCL23 measurement
1
1
1
60.8
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
protein measurement
1
73
protein measurement
1
73
fetal genotype effect measurement
1
73
fetal genotype effect measurement
1
73
CCL23 measurement
1
60.8
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16663-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Chemokine signaling pathway
KEGG
Cytokine-cytokine receptor interaction
KEGG
Viral protein interaction with cytokine and cytokine receptor
Name
Explore in Pharos
Explore in Source
Chemokine signaling pathway
Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
CCR1
Tchem
Family: GPCR
Novelty: 0.00218065
Score: 0.955
Data Source: STRINGDB
CCR3
Tchem
Family: GPCR
Novelty: 0.00197059
Score: 0.937
Data Source: STRINGDB
CCL2
Tchem
Novelty: 0.00010958
Score: 0.873
Data Source: STRINGDB
CCR2
Tchem
Family: GPCR
Novelty: 0.0006525
Score: 0.765
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.754
Data Source: STRINGDB
CXCR1
Tchem
Family: GPCR
Novelty: 0.00224501
Score: 0.735
Data Source: STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.73
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.727
Data Source: STRINGDB
CXCR4
Tclin
Family: GPCR
Novelty: 0.0002811
Score: 0.725
Data Source: STRINGDB
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
Score: 0.723
Data Source: STRINGDB
Publication Statistics
PubMed Score  93.94

PubMed score by year
PubTator Score  54.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer