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Tbio
GUCA2B
Guanylate cyclase activator 2B

Protein Summary
Description
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372581
  • ENSP00000361662
  • ENSG00000044012

Symbol
  • UGN
  • GCAP-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.8
disease perturbation
0.68
gene perturbation
0.53
transcription factor
0.5
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.56   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.977
Data Source:  Reactome,STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.752
Data Source:  STRINGDB
GUCA2A
Tbio
Novelty:  0.00856211
Score:  0.736
Data Source:  STRINGDB
TMIGD1
Tbio
Novelty:  0.21889871
Score:  0.728
Data Source:  STRINGDB
GUCA1B
Tbio
Family:  Enzyme
Novelty:  0.02031715
Score:  0.717
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.701
Data Source:  STRINGDB
PDZD3
Tbio
Novelty:  0.08821289
Score:  0.69
Data Source:  STRINGDB
EMD
Tbio
Novelty:  0.00135202
Score:  0.651
Data Source:  STRINGDB
OTOP2
Tdark
Novelty:  0.40535125
Score:  0.618
Data Source:  STRINGDB
MS4A12
Tdark
Novelty:  0.24047034
Score:  0.603
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (118)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2B
VGNC:6855
469301
Macaque
guanylate cyclase activator 2B
699525
Mouse
MGI:1270851
14916
Rat
RGD:620044
64055
Dog
guanylate cyclase activator 2B
VGNC:41565
100684829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2B
Macaque
guanylate cyclase activator 2B
Mouse
Rat
Dog
guanylate cyclase activator 2B
Publication Statistics
PubMed Score 53.56
PubMed score by year
PubTator Score 75.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title