Tbio MAPK6 Mitogen-activated protein kinase 6

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 6

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Erk Subfamily / Mitogen-activated Protein Kinase 6

Protein Summary

Description

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16659
• B2R945
• B5BU65
• Q68DH4
• Q8IYN8
• MAP kinase 6

Gene Name

• MAPK6

Ensembl ID

• ENST00000261845
• ENSP00000261845
• ENSG00000069956

Symbol

• ERK3
• PRKM6
• ERK3
• PRKM6
• p97MAPK
• HsT17250

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.97
transcription factor binding site profile	0.89
pathway	0.86

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.58   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 497   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.58   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (26)

Reactome (3)

KEGG (1)

PathwayCommons (4)

WikiPathways (18)

MAPK family signaling cascades (R-HSA-5683057)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	MAPK family signaling cascades	293 targets	R-HSA-5683057
Reactome	MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
MAPK family signaling cascades	293 targets	R-HSA-5683057
MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (18)

Functions (5)

Components (6)

Processes (7)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
MAP kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (183)

Explore Interacting Targets

1 – 10 of 183

• See Interactions on String-DB

MAPKAPK5

Tchem

Family: Kinase

Novelty: 0.01278004

p_int: 0.999999998

p_ni: 1e-9

p_wrong: 2e-9

Score: 0.978

Data Source: BioPlex,Reactome,STRINGDB

MAPK4

Tbio

Family: Kinase

Novelty: 0.04156197

p_int: 0.999999998

p_wrong: 2e-9

Score: 0.903

Data Source: BioPlex,STRINGDB

APOA1

Tbio

Novelty: 0.0001431

p_int: 0.999996099

p_ni: 0.000003897

p_wrong: 5e-9

Data Source: BioPlex

ZNF7

Tdark

Family: TF

Novelty: 0.27126391

p_int: 0.999994112

p_ni: 0.000005798

p_wrong: 9.1e-8

Score: 0.272

Data Source: BioPlex,STRINGDB

SERPINA1

Tbio

Novelty: 0.00017409

p_int: 0.999992378

p_ni: 0.000007622

Data Source: BioPlex

FGB

Tbio

Novelty: 0.00757235

p_int: 0.999970544

p_ni: 0.000029456

Data Source: BioPlex

HP

Tbio

Novelty: 0.00019588

p_int: 0.99987588

p_ni: 0.000124115

p_wrong: 4e-9

Score: 0.176

Data Source: BioPlex,STRINGDB

HBB

Tbio

Novelty: 0.00039916

p_int: 0.99974036

p_ni: 0.000256272

p_wrong: 0.000003368

Data Source: BioPlex

FGG

Tbio

Novelty: 0.00622014

p_int: 0.999718125

p_ni: 0.000251362

p_wrong: 0.000030514

Data Source: BioPlex

FGA

Tbio

Novelty: 0.00122914

p_int: 0.999557232

p_ni: 0.000373848

p_wrong: 0.000068921

Score: 0.165

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  61.58

PubMed score by year

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PubTator Score  29.62

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Sequence

MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIR

1-70

RLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGL

70-140

KYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYT

140-210

KAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQ

210-280

LLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSH

280-350

IYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYS

350-420

TEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKK

420-490

GKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQL

490-560

ELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLD

560-630

KFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPS

630-700

AMKSSPQIPHQTYSSILKHLN

700-721

MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN

Find similar targets by:

Uniprot Keyword

3D-structure
ATP-binding
Cell cycle
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism