You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAPK6
Mitogen-activated protein kinase 6

Protein Summary
Description
Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261845
  • ENSP00000261845
  • ENSG00000069956

Symbol
  • ERK3
  • PRKM6
  • ERK3
  • PRKM6
  • p97MAPK
  • HsT17250
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
molecular function
0.99
transcription factor perturbation
0.97
transcription factor binding site profile
0.89
pathway
0.86


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 497   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
1
1
74.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
1
74.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 6
VGNC:7529
453439
Mouse
MGI:1354946
50772
Rat
RGD:62087
58840
Dog
mitogen-activated protein kinase 6
VGNC:42999
478311
Horse
mitogen-activated protein kinase 6
VGNC:19960
100055006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 6
Mouse
Rat
Dog
mitogen-activated protein kinase 6
Horse
mitogen-activated protein kinase 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16659-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Signal Transduction
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (183)
1 – 10 of 183
MAPKAPK5
Tchem
Family: Kinase
Novelty: 0.01349079
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.978
Data Source: BioPlex,Reactome,STRINGDB
MAPK4
Tbio
Family: Kinase
Novelty: 0.0223868
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.903
Data Source: BioPlex,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
p_int: 0.999996099
p_ni: 0.000003897
p_wrong: 5e-9
Data Source: BioPlex
ZNF7
Tbio
Family: TF
Novelty: 0.13034184
p_int: 0.999994112
p_ni: 0.000005798
p_wrong: 9.1e-8
Score: 0.272
Data Source: BioPlex,STRINGDB
SERPINA1
Tbio
Novelty: 0.00014098
p_int: 0.999992378
p_ni: 0.000007622
Data Source: BioPlex
FGB
Tbio
Novelty: 0.00437751
p_int: 0.999970544
p_ni: 0.000029456
Data Source: BioPlex
HP
Tbio
Novelty: 0.00016649
p_int: 0.99987588
p_ni: 0.000124115
p_wrong: 4e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
HBB
Tbio
Novelty: 0.00049683
p_int: 0.99974036
p_ni: 0.000256272
p_wrong: 0.000003368
Data Source: BioPlex
FGG
Tbio
Novelty: 0.00404457
p_int: 0.999718125
p_ni: 0.000251362
p_wrong: 0.000030514
Data Source: BioPlex
FGA
Tbio
Novelty: 0.00107227
p_int: 0.999557232
p_ni: 0.000373848
p_wrong: 0.000068921
Score: 0.165
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  102.80

PubMed score by year
PubTator Score  29.62

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: