Tchem MAPK6 Mitogen-activated protein kinase 6

Protein Summary

Description

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16659
• B2R945
• B5BU65
• Q68DH4
• Q8IYN8
• MAP kinase 6

Gene Name

• MAPK6

Ensembl ID

• ENST00000261845
• ENSP00000261845
• ENSG00000069956

Symbol

• ERK3
• PRKM6
• ERK3
• PRKM6
• p97MAPK
• HsT17250

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.97
transcription factor binding site profile	0.89
pathway	0.86

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 6

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Erk Subfamily / Mitogen-activated Protein Kinase 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.29   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 497   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.29   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0