Tbio MAPK6 Mitogen-activated protein kinase 6

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 6

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / Erk Subfamily / Mitogen-activated Protein Kinase 6

Protein Summary

Description

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16659
• B2R945
• B5BU65
• Q68DH4
• Q8IYN8
• MAP kinase 6

Gene Name

• MAPK6

Ensembl ID

• ENST00000261845
• ENSP00000261845
• ENSG00000069956

Symbol

• ERK3
• PRKM6
• ERK3
• PRKM6
• p97MAPK
• HsT17250

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
molecular function	0.99
transcription factor perturbation	0.97
transcription factor binding site profile	0.89
pathway	0.86

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 497   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.8   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 497   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1	1	1		74.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
C-reactive protein measurement	EFO_0004458	1		74.7

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Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	mitogen-activated protein kinase 6	VGNC:7529	453439
Mouse	mitogen-activated protein kinase 6	MGI:1354946	50772
Rat	mitogen-activated protein kinase 6	RGD:62087	58840
Dog	mitogen-activated protein kinase 6	VGNC:42999	478311
Horse	mitogen-activated protein kinase 6	VGNC:19960	100055006

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitogen-activated protein kinase 6
Mouse	mitogen-activated protein kinase 6
Rat	mitogen-activated protein kinase 6
Dog	mitogen-activated protein kinase 6
Horse	mitogen-activated protein kinase 6

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16659-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (26)

Reactome (3)

KEGG (1)

PathwayCommons (4)

WikiPathways (18)

MAPK family signaling cascades (R-HSA-5683057)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	MAPK family signaling cascades	293 targets	R-HSA-5683057
Reactome	MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
MAPK family signaling cascades	293 targets	R-HSA-5683057
MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128
Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (18)

Functions (5)

Components (6)

Processes (7)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
MAP kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (183)

Explore Interacting Targets

1 – 10 of 183

• See Interactions on String-DB

MAPKAPK5

Tchem

Family: Kinase

Novelty: 0.01349079

p_int: 0.999999998

p_ni: 1e-9

p_wrong: 2e-9

Score: 0.978

Data Source: BioPlex,Reactome,STRINGDB

MAPK4

Tbio

Family: Kinase

Novelty: 0.0223868

p_int: 0.999999998

p_wrong: 2e-9

Score: 0.903

Data Source: BioPlex,STRINGDB

APOA1

Tbio

Novelty: 0.0001216

p_int: 0.999996099

p_ni: 0.000003897

p_wrong: 5e-9

Data Source: BioPlex

ZNF7

Tbio

Family: TF

Novelty: 0.13034184

p_int: 0.999994112

p_ni: 0.000005798

p_wrong: 9.1e-8

Score: 0.272

Data Source: BioPlex,STRINGDB

SERPINA1

Tbio

Novelty: 0.00014098

p_int: 0.999992378

p_ni: 0.000007622

Data Source: BioPlex

FGB

Tbio

Novelty: 0.00437751

p_int: 0.999970544

p_ni: 0.000029456

Data Source: BioPlex

HP

Tbio

Novelty: 0.00016649

p_int: 0.99987588

p_ni: 0.000124115

p_wrong: 4e-9

Score: 0.176

Data Source: BioPlex,STRINGDB

HBB

Tbio

Novelty: 0.00049683

p_int: 0.99974036

p_ni: 0.000256272

p_wrong: 0.000003368

Data Source: BioPlex

FGG

Tbio

Novelty: 0.00404457

p_int: 0.999718125

p_ni: 0.000251362

p_wrong: 0.000030514

Data Source: BioPlex

FGA

Tbio

Novelty: 0.00107227

p_int: 0.999557232

p_ni: 0.000373848

p_wrong: 0.000068921

Score: 0.165

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  102.80

PubMed score by year

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PubTator Score  29.62

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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Ortholog Sequence Conservation

WebLogo Color Code

PolarG S T Y C

NeutralQ N

BasicK R H

AcidicD E

HydrophobicA V L I P W F M

Compare across kinases on ProKinO

Structural Annotations

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
ATP-binding
Cell cycle
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

C-reactive protein measurement

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
liver/biliary system phenotype
mortality/aging
respiratory system phenotype
skeleton phenotype