MAPK6
Mitogen-activated protein kinase 6
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.99 | ||
molecular function | 0.99 | ||
transcription factor perturbation | 0.97 | ||
transcription factor binding site profile | 0.89 | ||
pathway | 0.86 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | MAPK family signaling cascades | ||||
Reactome | MAPK6/MAPK4 signaling | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
MAPK family signaling cascades | ||||
MAPK6/MAPK4 signaling | ||||
Signal Transduction | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
cognitive function measurement | 2 | 1 | 2 | 48.5 | |||||
self reported educational attainment | 1 | 1 | 1 | 46.9 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 46.1 | |||||
frailty measurement | 1 | 1 | 1 | 17.8 | |||||
intelligence | 1 | 1 | 0 | 5.4 | 14.2 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
cognitive function measurement | 2 | 48.5 | |||||
self reported educational attainment | 1 | 46.9 | |||||
C-reactive protein measurement | 1 | 46.1 | |||||
frailty measurement | 1 | 17.8 | |||||
intelligence | 0 | 5.4 | 14.2 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase 6 | VGNC:7529 | 453439 | |||||
Mouse | MGI:1354946 | 50772 | ||||||
Rat | RGD:62087 | 58840 | ||||||
Dog | mitogen-activated protein kinase 6 | VGNC:42999 | 478311 | |||||
Horse | mitogen-activated protein kinase 6 | VGNC:19960 | 100055006 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase 6 | |||||
Horse | mitogen-activated protein kinase 6 | |||||
PMID | Year | Title |
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