Pharos : Target Details

Tbio

Protein Summary

Description

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

Gene Name

MAPK6

Ensembl ID

ENST00000261845
ENSP00000261845
ENSG00000069956

Symbol

ERK3
PRKM6
ERK3
PRKM6
p97MAPK
HsT17250

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99

molecular function	0.99

transcription factor perturbation	0.97

transcription factor binding site profile	0.89

pathway	0.86

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.62 (req: < 5)

View Publications

Gene RIFs: 12 (req: <= 3)

View Gene RIFs

Antibodies: 497 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.62 (req: >= 5)

Gene RIFs: 12 (req: > 3)

Antibodies: 497 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

View Data

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (183)

1 – 10 of 183

See Interactions on String-DB

MAPKAPK5

Tchem

Family: Kinase

Novelty: 0.01349079

p_int: 0.999999998

p_ni: 1e-9

p_wrong: 2e-9

Score: 0.978

Data Source: BioPlex,Reactome,STRINGDB

MAPK4

Tbio

Family: Kinase

Novelty: 0.0223868

p_int: 0.999999998

p_wrong: 2e-9

Score: 0.903

Data Source: BioPlex,STRINGDB

APOA1

Tbio

Novelty: 0.0001216

p_int: 0.999996099

p_ni: 0.000003897

p_wrong: 5e-9

Data Source: BioPlex

ZNF7

Tbio

Family: TF

Novelty: 0.13034184

p_int: 0.999994112

p_ni: 0.000005798

p_wrong: 9.1e-8

Score: 0.272

Data Source: BioPlex,STRINGDB

SERPINA1

Tbio

Novelty: 0.00014098

p_int: 0.999992378

p_ni: 0.000007622

Data Source: BioPlex

FGB

Tbio

Novelty: 0.00437751

p_int: 0.999970544

p_ni: 0.000029456

Data Source: BioPlex

Tbio

Novelty: 0.00016649

p_int: 0.99987588

p_ni: 0.000124115

p_wrong: 4e-9

Score: 0.176

Data Source: BioPlex,STRINGDB

HBB

Tbio

Novelty: 0.00049683

p_int: 0.99974036

p_ni: 0.000256272

p_wrong: 0.000003368

Data Source: BioPlex

FGG

Tbio

Novelty: 0.00404457

p_int: 0.999718125

p_ni: 0.000251362

p_wrong: 0.000030514

Data Source: BioPlex

FGA

Tbio

Novelty: 0.00107227

p_int: 0.999557232

p_ni: 0.000373848

p_wrong: 0.000068921

Score: 0.165

Data Source: BioPlex,STRINGDB

Pathways (26)

Reactome (3)

KEGG (1)

PathwayCommons (4)

WikiPathways (18)

MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	MAPK family signaling cascades	293 targets	R-HSA-5683057

Reactome	MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128

Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
MAPK family signaling cascades	293 targets	R-HSA-5683057

MAPK6/MAPK4 signaling	92 targets	R-HSA-5687128

Signal Transduction	2704 targets	R-HSA-162582

Gene Ontology Terms (18)

Functions (5)

Components (6)

Processes (7)

Items per page:

1 – 5 of 5

GO Term	Evidence	Assigned by
MAP kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

protein serine/threonine kinase activity	Traceable Author Statement (TAS)	Reactome

ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	Ensembl

protein kinase binding	Inferred from Electronic Annotation (IEA)	Ensembl

GWAS Traits (6)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
cognitive function measurement	EFO_0008354	2	1	2		48.5

self reported educational attainment	EFO_0004784	1	1	1		46.9

C-reactive protein measurement	EFO_0004458	1	1	1		46.1

frailty measurement	EFO_0009885	1	1	1		17.8

intelligence	EFO_0004337	1	1	0	5.4	14.2

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
cognitive function measurement	EFO_0008354	2		48.5

self reported educational attainment	EFO_0004784	1		46.9

C-reactive protein measurement	EFO_0004458	1		46.1

frailty measurement	EFO_0009885	1		17.8

intelligence	EFO_0004337	0	5.4	14.2

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
3D-structure

ATP-binding

Cell cycle

Complete proteome

Cytoplasm

Kinase

Nucleotide-binding

Nucleus

Phosphoprotein

Polymorphism

GWAS Trait

MGI Phenotype

No Header	No Header
behavior/neurological phenotype

cardiovascular system phenotype

growth/size/body region phenotype

homeostasis/metabolism phenotype

integument phenotype

liver/biliary system phenotype

mortality/aging

respiratory system phenotype

skeleton phenotype

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID
Chimp	mitogen-activated protein kinase 6	VGNC:7529	453439

Mouse	mitogen-activated protein kinase 6	MGI:1354946	50772

Rat	mitogen-activated protein kinase 6	RGD:62087	58840

Dog	mitogen-activated protein kinase 6	VGNC:42999	478311

Horse	mitogen-activated protein kinase 6	VGNC:19960	100055006

Species	Name	OMA	EggNOG	Inparanoid
Chimp	mitogen-activated protein kinase 6

Mouse	mitogen-activated protein kinase 6

Rat	mitogen-activated protein kinase 6

Dog	mitogen-activated protein kinase 6

Horse	mitogen-activated protein kinase 6

Publication Statistics

PubMed Score 106.62

PubMed score by year

PubTator Score 29.62

PubTator score by year

Patents

Patents by year