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Tbio
NRF1
Nuclear respiratory factor 1

Protein Summary
Description
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223190
  • ENSP00000223190
  • ENSG00000106459
  • ENST00000311967
  • ENSP00000309826
  • ENST00000353868
  • ENSP00000342351
  • ENST00000393230
  • ENSP00000376922
  • ENST00000393232
  • ENSP00000376924

Symbol
  • ALPHA-PAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor binding site profile
0.95
disease perturbation
0.87
histone modification site profile
0.86
transcription factor
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.71   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.71   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
WDR59
Tdark
Novelty:  0.22243351
p_int:  0.999948777
p_ni:  5.3e-8
p_wrong:  0.00005117
Score:  0.297
Data Source:  BioPlex,STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.993
Data Source:  STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.98
Data Source:  Reactome,STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.977
Data Source:  STRINGDB
PPRC1
Tbio
Novelty:  0.00182088
Score:  0.967
Data Source:  Reactome,STRINGDB
TFB1M
Tbio
Family:  Enzyme
Novelty:  0.0236373
Score:  0.963
Data Source:  STRINGDB
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
Score:  0.957
Data Source:  STRINGDB
TFB2M
Tbio
Family:  Enzyme
Novelty:  0.02345237
Score:  0.954
Data Source:  STRINGDB
ESRRA
Tchem
Family:  NR
Novelty:  0.003235
Score:  0.953
Data Source:  STRINGDB
PPARGC1B
Tbio
Novelty:  0.01004477
Score:  0.945
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (30)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Mitochondrial biogenesis
Organelle biogenesis and maintenance
PPARA activates gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
AgBase
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
71.8
red blood cell distribution width
2
2
2
36.5
platelet crit
2
2
2
32.8
creatinine measurement
1
1
1
31.4
mean platelet volume
2
1
2
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
71.8
red blood cell distribution width
2
36.5
platelet crit
2
32.8
creatinine measurement
1
31.4
mean platelet volume
2
21.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear respiratory factor 1
VGNC:4450
472513
Mouse
MGI:1332235
18181
Rat
RGD:1304603
312195
Dog
nuclear respiratory factor 1
VGNC:43966
482260
Horse
nuclear respiratory factor 1
VGNC:20882
100056975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear respiratory factor 1
Mouse
Rat
Dog
nuclear respiratory factor 1
Horse
nuclear respiratory factor 1
Publication Statistics
PubMed Score 190.71
PubMed score by year
PubTator Score 238.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title