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Tbio
MLANA
Melanoma antigen recognized by T-cells 1

Protein Summary
Description
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381471
  • ENSP00000370880
  • ENSG00000120215
  • ENST00000381476
  • ENSP00000370885
  • ENST00000381477
  • ENSP00000370886

Symbol
  • MART1
  • MART1
  • MART-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
cell line
0.72
cellular component
0.68
biological term
0.67
PubMedID
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1420.73   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 2080   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1420.73   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 2080   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
32.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melan-A
VGNC:4786
464984
Mouse
MGI:108454
77836
Rat
RGD:1306525
293890
Dog
melan-A
VGNC:43254
403495
Horse
melan-A
VGNC:20207
100051824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melan-A
Mouse
Rat
Dog
melan-A
Horse
melan-A
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (108)
1 – 10 of 108
PMEL
Tbio
Novelty: 0.00116525
Score: 0.981
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00048513
Score: 0.975
Data Source: STRINGDB
TYRP1
Tbio
Family: Enzyme
Novelty: 0.00062138
Score: 0.911
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00094044
Score: 0.879
Data Source: STRINGDB
GPR143
Tbio
Family: GPCR
Novelty: 0.01507388
Score: 0.836
Data Source: STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.835
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tchem
Novelty: 0.00240724
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  1420.73

PubMed score by year
PubTator Score  308.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer