Tbio MLANA Melanoma antigen recognized by T-cells 1

Protein Summary

Description

Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.

Uniprot Accession IDs

• Q16655
• Q6ICU4
• MART-1

Gene Name

• MLANA

Ensembl ID

• ENST00000381471
• ENSP00000370880
• ENSG00000120215
• ENST00000381476
• ENSP00000370885
• ENST00000381477
• ENSP00000370886

Symbol

• MART1
• MART1
• MART-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.77
cell line	0.72
cellular component	0.68
biological term	0.67
PubMedID	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.18   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 2080   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1757.18   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 2080   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0