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Tbio
MLANA
Melanoma antigen recognized by T-cells 1

Protein Summary
Description
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381471
  • ENSP00000370880
  • ENSG00000120215
  • ENST00000381476
  • ENSP00000370885
  • ENST00000381477
  • ENSP00000370886

Symbol
  • MART1
  • MART1
  • MART-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
cell line
0.72
cellular component
0.68
biological term
0.67
PubMedID
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.07   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 2080   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 984.07   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 2080   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (108)
1 – 10 of 108
PMEL
Tbio
Novelty: 0.00174298
Score: 0.981
Data Source: STRINGDB
TYR
Tclin
Family: Enzyme
Novelty: 0.00007229
Score: 0.975
Data Source: STRINGDB
TYRP1
Tbio
Family: Enzyme
Novelty: 0.00076485
Score: 0.911
Data Source: STRINGDB
MITF
Tbio
Family: TF
Novelty: 0.00112891
Score: 0.879
Data Source: STRINGDB
GPR143
Tbio
Family: GPCR
Novelty: 0.01765091
Score: 0.836
Data Source: STRINGDB
HLA-DRA
Tbio
Novelty: 0.00705028
Score: 0.835
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00375288
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00375288
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tchem
Novelty: 0.00375288
Score: 0.808
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00375288
Score: 0.808
Data Source: STRINGDB
Publication Statistics
PubMed Score  984.07

PubMed score by year
PubTator Score  308.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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