Tchem PRSS8 Prostasin

Protein Summary

Description

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q16651
• B4DWP2
• Q9UCA3

Gene Name

• PRSS8

Ensembl ID

• ENST00000317508
• ENSP00000319730
• ENSG00000052344
• ENST00000568261
• ENSP00000457750

Symbol

• CAP1
• PROSTASIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
PubMedID	0.9
cellular component	0.72
transcription factor perturbation	0.61
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Prostasin

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Prostasin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.37   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.37   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0