Tchem PRSS8 Prostasin

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Prostasin

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Prostasin

Protein Summary

Description

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• Q16651
• B4DWP2
• Q9UCA3

Gene Name

• PRSS8

Ensembl ID

• ENST00000317508
• ENSP00000319730
• ENSG00000052344
• ENST00000568261
• ENSP00000457750

Symbol

• CAP1
• PROSTASIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
PubMedID	0.9
cellular component	0.72
transcription factor perturbation	0.61
protein domain	0.58

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.25   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.25   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (15)

Explore Active Ligands

1 – 10 of 15

B3C

PRSS8Tchem Enzyme

Ki : 7.92000008

CHEMBL505558

PRSS8Tchem Enzyme

Ki : 7.92

CHEMBL500474,CHEMBL498914

PRSS8Tchem Enzyme

Ki : 7.4

CHEMBL505738

PRSS8Tchem Enzyme

Ki : 7.57

CHEMBL505048

PRSS8Tchem Enzyme

Ki : 7.55

CHEMBL476038

PRSS8Tchem Enzyme

Ki : 7.54

CHEMBL443101

PRSS8Tchem Enzyme

Ki : 7.39

CHEMBL506226

PRSS8Tchem Enzyme

Ki : 7.35

CHEMBL500835

PRSS8Tchem Enzyme

Ki : 7.22

CHEMBL446259

PRSS8Tchem Enzyme

Ki : 7.19

GWAS Traits (25)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 25

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	1	3	3		82.8
response to anticoagulant	GO_0061476	1	1	0	20.4	81
triglyceride measurement	EFO_0004530	3	3	3		72.3
body mass index	EFO_0004340	5	2	6		71.6
waist circumference	EFO_0004342	2	2	2		67.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
IGF-1 measurement	EFO_0004627	3		82.8
response to anticoagulant	GO_0061476	0	20.4	81
triglyceride measurement	EFO_0004530	3		72.3
body mass index	EFO_0004340	6		71.6
waist circumference	EFO_0004342	2		67.4

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	serine protease 8	VGNC:5903	454065
Macaque	protease, serine 8		713176
Mouse	protease, serine 8 (prostasin)	MGI:1923810	76560
Rat	serine protease 8	RGD:619973	192107
Dog	serine protease 8	VGNC:45074	102157328

Species	Name	OMA	EggNOG	Inparanoid
Chimp	serine protease 8
Macaque	protease, serine 8
Mouse	protease, serine 8 (prostasin)
Rat	serine protease 8
Dog	serine protease 8

Protein Structure (9 Structures, 1 AlphaFold Model)

tutorial

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16651-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Developmental Biology (R-HSA-1266738)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Formation of the cornified envelope	75 targets	R-HSA-6809371
Reactome	Keratinization	217 targets	R-HSA-6805567

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Formation of the cornified envelope	75 targets	R-HSA-6809371
Keratinization	217 targets	R-HSA-6805567

Gene Ontology Terms (13)

Functions (4)

Components (7)

Processes (2)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
sodium channel regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
endopeptidase activity	Traceable Author Statement (TAS)	Reactome
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc
serine-type endopeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (37)

Explore Interacting Targets

1 – 10 of 37

• See Interactions on String-DB

FLG

Tbio

Novelty:  0.00072986

Score:  0.942

Data Source:  Reactome,STRINGDB

SPINT1

Tbio

Family:  Enzyme

Novelty:  0.00930324

Score:  0.916

Data Source:  STRINGDB

SPINT2

Tbio

Family:  Enzyme

Novelty:  0.0046602

Score:  0.849

Data Source:  STRINGDB

CLDN7

Tbio

Novelty:  0.00722366

Score:  0.721

Data Source:  STRINGDB

SCNN1A

Tclin

Family:  IC

Novelty:  0.00900102

Score:  0.717

Data Source:  STRINGDB

KAT8

Tchem

Family:  Epigenetic

Novelty:  0.00861497

Score:  0.709

Data Source:  STRINGDB

CDH1

Tbio

Novelty:  0.00010629

Score:  0.69

Data Source:  STRINGDB

RAB25

Tbio

Family:  Enzyme

Novelty:  0.01889483

Score:  0.69

Data Source:  STRINGDB

SCNN1G

Tclin

Family:  IC

Novelty:  0.00689941

Score:  0.679

Data Source:  STRINGDB

BCKDK

Tbio

Family:  Kinase

Novelty:  0.03296998

Score:  0.642

Data Source:  STRINGDB

Publication Statistics

PubMed Score  136.25

PubMed score by year

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PubTator Score  93.19

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Membrane
Protease

GWAS Trait Find Similar Targets

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MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
embryo phenotype
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growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
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mortality/aging