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Tchem
PRSS8
Prostasin

Protein Summary
Description
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317508
  • ENSP00000319730
  • ENSG00000052344
  • ENST00000568261
  • ENSP00000457750

Symbol
  • CAP1
  • PROSTASIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
PubMedID
0.9
cellular component
0.72
transcription factor perturbation
0.61
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.27   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.27   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 8
VGNC:5903
454065
Macaque
protease, serine 8
713176
Mouse
MGI:1923810
76560
Rat
RGD:619973
192107
Dog
serine protease 8
VGNC:45074
102157328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 8
Macaque
protease, serine 8
Mouse
Rat
Dog
serine protease 8
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16651-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (37)
1 – 10 of 37
FLG
Tbio
Novelty: 0.00072986
Score: 0.942
Data Source: Reactome,STRINGDB
SPINT1
Tbio
Family: Enzyme
Novelty: 0.00930324
Score: 0.916
Data Source: STRINGDB
SPINT2
Tbio
Family: Enzyme
Novelty: 0.0046602
Score: 0.849
Data Source: STRINGDB
CLDN7
Tbio
Novelty: 0.00722366
Score: 0.721
Data Source: STRINGDB
SCNN1A
Tclin
Family: IC
Novelty: 0.00900102
Score: 0.717
Data Source: STRINGDB
KAT8
Tchem
Family: Epigenetic
Novelty: 0.00861497
Score: 0.709
Data Source: STRINGDB
CDH1
Tbio
Novelty: 0.00010629
Score: 0.69
Data Source: STRINGDB
RAB25
Tbio
Family: Enzyme
Novelty: 0.01889483
Score: 0.69
Data Source: STRINGDB
SCNN1G
Tclin
Family: IC
Novelty: 0.00689941
Score: 0.679
Data Source: STRINGDB
BCKDK
Tbio
Family: Kinase
Novelty: 0.03296998
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  132.27

PubMed score by year
PubTator Score  93.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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