Protein Classes
Protein Summary
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
- ENST00000317508
- ENSP00000319730
- ENSG00000052344
- ENST00000568261
- ENSP00000457750
- CAP1
- PROSTASIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
PubMedID | 0.9 | ||
cellular component | 0.72 | ||
transcription factor perturbation | 0.61 | ||
protein domain | 0.58 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.27 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 273 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 132.27 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 273 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (15)
1 – 10 of 15
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serine protease 8 | VGNC:5903 | 454065 | |||||
Macaque | protease, serine 8 | 713176 | ||||||
Mouse | MGI:1923810 | 76560 | ||||||
Rat | RGD:619973 | 192107 | ||||||
Dog | serine protease 8 | VGNC:45074 | 102157328 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serine protease 8 | |||||
Macaque | protease, serine 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serine protease 8 | |||||
Protein Structure (9 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Gene Ontology Terms (13)
Functions (4)
Components (7)
Processes (2)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (37)
1 – 10 of 37
FLG
Novelty: 0.00072986
Score: 0.942
Data Source: Reactome,STRINGDB
SPINT1
Family: Enzyme
Novelty: 0.00930324
Score: 0.916
Data Source: STRINGDB
SPINT2
Family: Enzyme
Novelty: 0.0046602
Score: 0.849
Data Source: STRINGDB
CLDN7
Novelty: 0.00722366
Score: 0.721
Data Source: STRINGDB
SCNN1A
Family: IC
Novelty: 0.00900102
Score: 0.717
Data Source: STRINGDB
KAT8
Family: Epigenetic
Novelty: 0.00861497
Score: 0.709
Data Source: STRINGDB
CDH1
Novelty: 0.00010629
Score: 0.69
Data Source: STRINGDB
RAB25
Family: Enzyme
Novelty: 0.01889483
Score: 0.69
Data Source: STRINGDB
SCNN1G
Family: IC
Novelty: 0.00689941
Score: 0.679
Data Source: STRINGDB
BCKDK
Family: Kinase
Novelty: 0.03296998
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score 132.27
PubMed score by year
PubTator Score 93.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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