Protein Classes
Protein Summary
Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
- ENST00000317508
- ENSP00000319730
- ENSG00000052344
- ENST00000568261
- ENSP00000457750
- CAP1
- PROSTASIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
PubMedID | 0.9 | ||
cellular component | 0.72 | ||
transcription factor perturbation | 0.61 | ||
protein domain | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.64 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 273 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 118.64 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 273 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (15)
1 – 10 of 15
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Formation of the cornified envelope | ||||
Reactome | Keratinization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Formation of the cornified envelope | ||||
Keratinization | ||||
Gene Ontology Terms (13)
Functions (4)
Components (7)
Processes (2)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (37)
1 – 10 of 37
FLG
Novelty: 0.0009107
Score: 0.942
Data Source: Reactome,STRINGDB
SPINT1
Family: Enzyme
Novelty: 0.01180495
Score: 0.916
Data Source: STRINGDB
SPINT2
Family: Enzyme
Novelty: 0.00575409
Score: 0.849
Data Source: STRINGDB
CLDN7
Novelty: 0.00860191
Score: 0.721
Data Source: STRINGDB
SCNN1A
Family: IC
Novelty: 0.01452921
Score: 0.717
Data Source: STRINGDB
KAT8
Family: Epigenetic
Novelty: 0.00470357
Score: 0.709
Data Source: STRINGDB
CDH1
Novelty: 0.0001303
Score: 0.69
Data Source: STRINGDB
RAB25
Family: Enzyme
Novelty: 0.01564847
Score: 0.69
Data Source: STRINGDB
SCNN1G
Family: IC
Novelty: 0.00766423
Score: 0.679
Data Source: STRINGDB
BCKDK
Family: Kinase
Novelty: 0.05449092
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score 118.64
PubMed score by year
PubTator Score 93.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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