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Tbio
TBR1
T-box brain protein 1

Protein Summary
Description
Probable transcriptional regulator involved in developmental processes. Required for normal brain development. This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of numerous developmental processes. In mouse, the ortholog of this gene is expressed in the cerebral cortex, hippocampus, amygdala and olfactory bulb and is thought to play an important role in neuronal migration and axonal projection. In mouse, the C-terminal region of this protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389554
  • ENSP00000374205
  • ENSG00000136535
  • ENST00000410035
  • ENSP00000387023

Symbol
  • IDDAS
  • TBR-1
  • TES-56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
biological process
0.7
molecular function
0.63
histone modification site profile
0.59
microRNA
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
54.4
cognitive function measurement
1
1
1
46.1
systolic blood pressure
1
1
1
44.2
smoking behavior
1
1
1
31.4
mathematical ability
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
54.4
cognitive function measurement
1
46.1
systolic blood pressure
1
44.2
smoking behavior
1
31.4
mathematical ability
1
21.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
T-box, brain 1
VGNC:2878
739449
Macaque
T-box, brain 1
701176
Mouse
MGI:107404
21375
Rat
RGD:1591773
680427
Dog
T-box, brain 1
VGNC:47166
488370
Species
Name
OMA
EggNOG
Inparanoid
Chimp
T-box, brain 1
Macaque
T-box, brain 1
Mouse
Rat
Dog
T-box, brain 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16650-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (122)
1 – 10 of 122
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
Score:  0.913
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.907
Data Source:  STRINGDB
FEZF2
Tbio
Family:  TF
Novelty:  0.01641588
Score:  0.88
Data Source:  STRINGDB
FOXP2
Tbio
Family:  TF
Novelty:  0.00190504
Score:  0.875
Data Source:  STRINGDB
BCL11B
Tbio
Family:  TF
Novelty:  0.00555596
Score:  0.838
Data Source:  STRINGDB
CUX1
Tbio
Family:  TF
Novelty:  0.00415896
Score:  0.833
Data Source:  STRINGDB
CUX1
Tbio
Novelty:  0.00415896
Score:  0.833
Data Source:  STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.821
Data Source:  STRINGDB
EMX1
Tbio
Family:  TF
Novelty:  0.00584996
Score:  0.805
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.782
Data Source:  STRINGDB
Publication Statistics
PubMed Score  148.23

PubMed score by year
PubTator Score  50.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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