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Tchem
MAPKAPK3
MAP kinase-activated protein kinase 3

Protein Summary
Description
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357955
  • ENSP00000350639
  • ENSG00000114738
  • ENST00000446044
  • ENSP00000396467
  • ENST00000621469
  • ENSP00000478922

Symbol
  • 3PK
  • MK-3
  • MDPT3
  • MAPKAP3
  • MAPKAP-K3
  • MAPKAPK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.95
biological process
0.9
protein domain
0.85
kinase perturbation
0.84


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.96   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.96   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL226403
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
55.9
self reported educational attainment
1
1
1
36.7
reticulocyte count
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
55.9
self reported educational attainment
1
36.7
reticulocyte count
1
7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase-activated protein kinase 3
VGNC:7983
460400
Macaque
mitogen-activated protein kinase-activated protein kinase 3
701320
Mouse
MGI:2143163
102626
Rat
RGD:1304980
315994
Dog
mitogen-activated protein kinase-activated protein kinase 3
VGNC:43007
484756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase-activated protein kinase 3
Macaque
mitogen-activated protein kinase-activated protein kinase 3
Mouse
Rat
Dog
mitogen-activated protein kinase-activated protein kinase 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16644-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (154)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Cytokine Signaling in Immune system
Immune System
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (98)
1 – 10 of 98
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 1
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
MAPK11
Tchem
Family: Kinase
Novelty: 0.00545217
p_int: 0.999999997
p_wrong: 3e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
PRKY
Tdark
Family: Kinase
p_int: 0.973821807
p_wrong: 0.026178193
Data Source: BioPlex
MAPK13
Tchem
Family: Kinase
Novelty: 0.01071621
Score: 0.985
Data Source: STRINGDB
HSPB1
Tchem
Novelty: 0.00081373
Score: 0.974
Data Source: STRINGDB
MAPK12
Tchem
Family: Kinase
Novelty: 0.00835017
Score: 0.969
Data Source: STRINGDB
PHC2
Tbio
Novelty: 0.01943349
Score: 0.947
Data Source: STRINGDB
RNF2
Tbio
Family: Enzyme
Novelty: 0.00859204
Score: 0.942
Data Source: STRINGDB
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
Score: 0.936
Data Source: STRINGDB
MAPK10
Tchem
Family: Kinase
Novelty: 0.00420573
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.96

PubMed score by year
PubTator Score  51.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer