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Tbio
DBN1
Drebrin

Protein Summary
Description
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292385
  • ENSP00000292385
  • ENSG00000113758
  • ENST00000309007
  • ENSP00000308532
  • ENST00000393565
  • ENSP00000377195

Symbol
  • D0S117E
  • D0S117E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
kinase perturbation
0.84
ligand (protein) perturbation
0.83
hub protein
0.82
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.95   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.95   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
HOMER2
Tbio
Novelty:  0.00820449
p_int:  0.999993298
p_ni:  0.000006702
Score:  0.87
Data Source:  BioPlex,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.99999191
p_ni:  0.00000809
Score:  0.789
Data Source:  BioPlex,STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.996376311
p_ni:  0.003623689
Score:  0.403
Data Source:  BioPlex,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.995441645
p_ni:  0.004558355
Score:  0.815
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.989141156
p_ni:  0.010858844
Score:  0.847
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.988636259
p_ni:  0.011363741
Score:  0.491
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.98820835
p_ni:  0.01179165
Score:  0.343
Data Source:  BioPlex,STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
p_int:  0.844649732
p_ni:  0.155350268
Score:  0.809
Data Source:  BioPlex,STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.846
Data Source:  STRINGDB
MAPRE3
Tbio
Novelty:  0.00454315
Score:  0.837
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
8
11
15.2
99.3
creatinine measurement
5
6
7
97
partial thromboplastin time
2
2
2
96.1
hematocrit
5
5
5
96.1
hemoglobin measurement
4
4
4
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15.2
99.3
creatinine measurement
7
97
partial thromboplastin time
2
96.1
hematocrit
5
96.1
hemoglobin measurement
4
94.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
drebrin 1
700375
Mouse
MGI:1931838
56320
Rat
RGD:70885
81653
Dog
drebrin 1
VGNC:39783
489088
Horse
drebrin 1
VGNC:17018
100068529
Species
Name
OMA
EggNOG
Inparanoid
Macaque
drebrin 1
Mouse
Rat
Dog
drebrin 1
Horse
drebrin 1
Publication Statistics
PubMed Score 197.95
PubMed score by year
PubTator Score 93.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title