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Tchem
SMN1
Survival motor neuron protein

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351205
  • ENSP00000305857
  • ENSG00000172062
  • ENST00000380707
  • ENSP00000370083
  • ENST00000380741
  • ENSP00000370117
  • ENSG00000205571
  • ENST00000380742
  • ENSP00000370118
  • ENST00000380743
  • ENSP00000370119
  • ENST00000503079
  • ENSP00000428128
  • ENST00000506163
  • ENSP00000424926
  • ENST00000611442
  • ENSP00000483768
  • ENSG00000277773
  • ENST00000614240
  • ENSP00000479279
  • ENST00000614610
  • ENSP00000479920
  • ENSG00000273772
  • ENST00000614773
  • ENSP00000481427
  • ENST00000618251
  • ENSP00000483515
  • ENST00000618661
  • ENSP00000483819
  • ENST00000622158
  • ENSP00000480906
  • ENSG00000275349
  • ENST00000622739
  • ENSP00000482966
  • ENST00000624634
  • ENSP00000485595
  • ENST00000626847
  • ENSP00000486152
  • ENST00000627341
  • ENSP00000487421
  • ENST00000628353
  • ENSP00000487029
  • ENST00000628642
  • ENSP00000487015
  • ENST00000629122
  • ENSP00000487206

Symbol
  • SMN
  • SMNT
  • SMA
  • SMN
  • SMA1
  • SMA2
  • SMA3
  • SMA4
  • SMA@
  • SMNT
  • BCD541
  • GEMIN1
  • TDRD16A
  • T-BCD541
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
biological term
0.79
cellular component
0.69
tissue sample
0.6
ligand (protein) perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.16   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 764.16   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (12)
Protein-Protein Interactions (115)
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.999989707
p_ni:  3e-9
p_wrong:  0.000010289
Score:  0.746
Data Source:  BioPlex,STRINGDB
GEMIN2
Tbio
Novelty:  0.02072868
Score:  0.999
Data Source:  STRINGDB
SNRPD1
Tbio
Novelty:  0.0136355
Score:  0.998
Data Source:  STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
Score:  0.998
Data Source:  STRINGDB
SNRPD2
Tbio
Novelty:  0.02519503
Score:  0.998
Data Source:  STRINGDB
SNRPG
Tbio
Novelty:  0.1684808
Score:  0.998
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.998
Data Source:  STRINGDB
DDX20
Tbio
Family:  Enzyme
Novelty:  0.01854078
Score:  0.997
Data Source:  STRINGDB
GEMIN8
Tbio
Novelty:  0.19515325
Score:  0.992
Data Source:  STRINGDB
GEMIN6
Tbio
Novelty:  0.02104816
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
42.3
blood protein measurement
1
1
1
42.3
blood protein measurement
1
1
1
42.3
myeloid white cell count
1
1
1
6.3
myeloid white cell count
1
1
1
6.3
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
42.3
blood protein measurement
1
42.3
blood protein measurement
1
42.3
myeloid white cell count
1
6.3
myeloid white cell count
1
6.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
survival motor neuron protein
461829
Macaque
survival of motor neuron 1, telomeric
677703
Mouse
MGI:109257
20595
Rat
RGD:620755
64301
Dog
survival motor neuron
403896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
survival motor neuron protein
Macaque
survival of motor neuron 1, telomeric
Mouse
Rat
Dog
survival motor neuron
Publication Statistics
PubMed Score 764.16
PubMed score by year
PubTator Score 3012.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title