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Tbio
SMN1
Survival motor neuron protein

Protein Summary
Description
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351205
  • ENSP00000305857
  • ENSG00000172062
  • ENST00000380707
  • ENSP00000370083
  • ENST00000380741
  • ENSP00000370117
  • ENSG00000205571
  • ENST00000380742
  • ENSP00000370118
  • ENST00000380743
  • ENSP00000370119
  • ENST00000503079
  • ENSP00000428128
  • ENST00000506163
  • ENSP00000424926
  • ENST00000611442
  • ENSP00000483768
  • ENSG00000277773
  • ENST00000614240
  • ENSP00000479279
  • ENST00000614610
  • ENSP00000479920
  • ENSG00000273772
  • ENST00000614773
  • ENSP00000481427
  • ENST00000618251
  • ENSP00000483515
  • ENST00000618661
  • ENSP00000483819
  • ENST00000622158
  • ENSP00000480906
  • ENSG00000275349
  • ENST00000622739
  • ENSP00000482966
  • ENST00000624634
  • ENSP00000485595
  • ENST00000626847
  • ENSP00000486152
  • ENST00000627341
  • ENSP00000487421
  • ENST00000628353
  • ENSP00000487029
  • ENST00000628642
  • ENSP00000487015
  • ENST00000629122
  • ENSP00000487206

Symbol
  • SMN
  • SMNT
  • SMA
  • SMN
  • SMA1
  • SMA2
  • SMA3
  • SMA4
  • SMA@
  • SMNT
  • BCD541
  • GEMIN1
  • TDRD16A
  • T-BCD541
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
biological term
0.79
cellular component
0.69
tissue sample
0.6
ligand (protein) perturbation
0.59


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.87   (req: < 5)
Gene RIFs: 199   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.87   (req: >= 5)
Gene RIFs: 199   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
survival motor neuron protein
461829
Macaque
survival of motor neuron 1, telomeric
677703
Mouse
MGI:109257
20595
Rat
RGD:620755
64301
Dog
survival motor neuron
403896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
survival motor neuron protein
Macaque
survival of motor neuron 1, telomeric
Mouse
Rat
Dog
survival motor neuron
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16637-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Metabolism of non-coding RNA
Reactome
snRNP Assembly
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Metabolism of non-coding RNA
snRNP Assembly
Gene Ontology Terms (19)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (115)
1 – 10 of 115
SNRNP70
Tbio
Novelty: 0.00116631
p_int: 0.999989707
p_ni: 3e-9
p_wrong: 0.000010289
Score: 0.746
Data Source: BioPlex,STRINGDB
GEMIN2
Tbio
Novelty: 0.02072868
Score: 0.999
Data Source: STRINGDB
SNRPD1
Tbio
Novelty: 0.0136355
Score: 0.998
Data Source: STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
Score: 0.998
Data Source: STRINGDB
SNRPD2
Tbio
Novelty: 0.02519503
Score: 0.998
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.998
Data Source: STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
Score: 0.998
Data Source: STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.01854078
Score: 0.997
Data Source: STRINGDB
GEMIN8
Tbio
Novelty: 0.19515325
Score: 0.992
Data Source: STRINGDB
GEMIN6
Tbio
Novelty: 0.02104816
Score: 0.992
Data Source: STRINGDB
Publication Statistics
PubMed Score  737.87

PubMed score by year
PubTator Score  3012.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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