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Tbio
TAZ
Tafazzin

Protein Summary
Description
Some isoforms may be involved in cardiolipin (CL) metabolism. This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000475699
  • ENSP00000419854
  • ENSG00000102125
  • ENST00000601016
  • ENSP00000469981
  • ENST00000612460
  • ENSP00000481037
  • ENST00000613002
  • ENSP00000478154

Symbol
  • EFE2
  • G4.5
  • EFE
  • BTHS
  • EFE2
  • G4.5
  • Taz1
  • CMD3A
  • LVNCX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
virus perturbation
0.83
cell type or tissue
0.78
cellular component
0.74
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.41   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 386   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.41   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (102)
Acyl chain remodeling of CL (R-HSA-1482798)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of CL
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial protein import
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of CL
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Mitochondrial protein import
Protein-Protein Interactions (181)
1 – 10 of 181
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.99997226
p_ni: 0.00002774
Score: 0.912
Data Source: BioPlex,STRINGDB
VWDE
Tdark
Novelty: 0.37298162
p_int: 0.999940362
p_ni: 0.000059638
Data Source: BioPlex
FUT11
Tbio
Family: Enzyme
Novelty: 0.16098097
p_int: 0.999732802
p_ni: 0.000266178
p_wrong: 0.00000102
Data Source: BioPlex
GALNT18
Tbio
Family: Enzyme
Novelty: 0.15496205
p_int: 0.999684075
p_ni: 0.000315923
p_wrong: 2e-9
Score: 0.532
Data Source: BioPlex,STRINGDB
CNTNAP3
Tdark
Novelty: 0.22791524
p_int: 0.999510424
p_ni: 0.000489575
Data Source: BioPlex
ADAM11
Tbio
Family: Enzyme
Novelty: 0.122537
p_int: 0.999267648
p_ni: 0.000646394
p_wrong: 0.000085958
Score: 0.173
Data Source: BioPlex,STRINGDB
ITGA8
Tbio
Novelty: 0.0220023
p_int: 0.997808871
p_ni: 0.002191111
p_wrong: 1.8e-8
Data Source: BioPlex
H6PD
Tbio
Novelty: 0.00366637
p_int: 0.996764445
p_ni: 0.002816923
p_wrong: 0.000418632
Score: 0.319
Data Source: BioPlex,STRINGDB
GALNS
Tbio
Family: Enzyme
Novelty: 0.00510529
p_int: 0.994576183
p_ni: 0.005423816
Score: 0.196
Data Source: BioPlex,STRINGDB
HYAL2
Tbio
Family: Enzyme
Novelty: 0.00740331
p_int: 0.993953787
p_ni: 0.006046174
p_wrong: 4e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  300.41

PubMed score by year
PubTator Score  454.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer