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Tbio
POU2AF1
POU domain class 2-associating factor 1

Protein Summary
Description
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393067
  • ENSP00000376786
  • ENSG00000110777

Symbol
  • OBF1
  • BOB1
  • OBF1
  • OCAB
  • OBF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
kinase perturbation
0.6
phenotype
0.55
tissue
0.55
PubMedID
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.58   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 502   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.58   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 502   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
2
0
1.1
90.7
1
1
0
1.1
80.3
hemoglobin measurement
2
2
2
72.3
hematocrit
2
2
2
68.3
urinary pH measurement
2
1
1
1.1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90.7
0
1.1
80.3
hemoglobin measurement
2
72.3
hematocrit
2
68.3
urinary pH measurement
1
1.1
61.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 2 associating factor 1
VGNC:1045
451537
Macaque
POU class 2 associating factor 1
709752
Mouse
MGI:105086
18985
Rat
RGD:1594728
690528
Dog
POU class 2 associating factor 1
VGNC:44825
489413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 2 associating factor 1
Macaque
POU class 2 associating factor 1
Mouse
Rat
Dog
POU class 2 associating factor 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16633-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (68)
1 – 10 of 68
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.930742877
p_ni:  0.069257123
Score:  0.519
Data Source:  BioPlex,STRINGDB
POU2F1
Tbio
Family:  TF
Novelty:  0.00722164
Score:  0.961
Data Source:  STRINGDB
POU2F2
Tbio
Family:  TF
Novelty:  0.02531524
Score:  0.847
Data Source:  STRINGDB
TNFRSF17
Tclin
Novelty:  0.00222663
Score:  0.846
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.843
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.807
Data Source:  STRINGDB
MZB1
Tbio
Novelty:  0.04147497
Score:  0.794
Data Source:  STRINGDB
GTF2I
Tbio
Family:  TF
Novelty:  0.00703345
Score:  0.734
Data Source:  STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.726
Data Source:  STRINGDB
IKZF3
Tbio
Family:  TF
Novelty:  0.01038728
Score:  0.724
Data Source:  STRINGDB
Publication Statistics
PubMed Score  131.58

PubMed score by year
PubTator Score  72.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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