Tbio CPSF6 Cleavage and polyadenylation specificity factor subunit 6

Protein Summary

Description

Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:20695905, PubMed:29276085). CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localized upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery (PubMed:15169763, PubMed:29276085, PubMed:21295486). Plays a role in mRNA export (PubMed:19864460). The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16630
• A8K7K9
• Q53ES1
• Q9BSJ7
• Q9BW18

Gene Name

• CPSF6

Ensembl ID

• ENST00000266679
• ENSP00000266679
• ENSG00000111605
• ENST00000435070
• ENSP00000391774

Symbol

• CFIM68
• CFIM
• CFIM68
• CFIM72
• HPBRII-4
• HPBRII-7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	0.82
transcription factor perturbation	0.8
interacting protein	0.76
hub protein	0.75
transcription factor	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Cleavage And Polyadenylation Specificity Factor Subunit 6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Cleavage And Polyadenylation Specificity Factor Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0