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Tbio
CCL14
C-C motif chemokine 14

Protein Summary
Description
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618404
  • ENSP00000481023
  • ENSG00000276409
  • ENST00000619040
  • ENSP00000483302
  • ENSG00000277236
  • ENST00000622526
  • ENSP00000479097
  • ENST00000632700
  • ENSP00000487948

Symbol
  • NCC2
  • SCYA14
  • CC-1
  • CC-3
  • CKB1
  • MCIF
  • NCC2
  • SY14
  • HCC-1
  • HCC-3
  • NCC-2
  • SCYL2
  • SCYA14
  • HCC-1(1-74)
  • HCC-1/HCC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.71
cell line
0.63
tissue sample
0.48
disease
0.46
phenotype
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.09   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.09   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0