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Tbio
OCLN
Occludin

Protein Summary
Description
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355237
  • ENSP00000347379
  • ENSG00000197822
  • ENST00000396442
  • ENSP00000379719
  • ENST00000538151
  • ENSP00000445940

Symbol
  • BLCPMG
  • PTORCH1
  • PPP1R115
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.98
kinase
0.96
PubMedID
0.92
chemical
0.85
biological term
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2116.66   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 439   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2116.66   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 439   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (221)
FBLN1
Tbio
Novelty:  0.00796703
p_int:  0.999967278
p_ni:  0.000032722
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999960281
p_ni:  3.3e-8
p_wrong:  0.000039686
Score:  0.297
Data Source:  BioPlex,STRINGDB
PLA2G16
Tchem
Novelty:  0.02310886
p_int:  0.998688483
p_ni:  0.001311514
p_wrong:  3e-9
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.99810321
p_ni:  0.001896789
p_wrong:  1e-9
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.998087876
p_ni:  0.001912098
p_wrong:  2.6e-8
Score:  0.293
Data Source:  BioPlex,STRINGDB
C4A
Tbio
Novelty:  0.00062793
p_int:  0.997900461
p_ni:  0.001475763
p_wrong:  0.000623776
Score:  0.155
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.997355459
p_ni:  0.002644539
p_wrong:  2e-9
Score:  0.267
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.995182593
p_ni:  0.004817405
p_wrong:  2e-9
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.990779393
p_ni:  0.009220607
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.982948372
p_ni:  0.017051628
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cell adhesion proteins
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cell adhesion proteins
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
occludin
VGNC:13559
741925
Macaque
occludin
700504
Mouse
MGI:106183
18260
Rat
RGD:620089
83497
Dog
occludin
VGNC:44094
403844
Species
Name
OMA
EggNOG
Inparanoid
Chimp
occludin
Macaque
occludin
Mouse
Rat
Dog
occludin
Publication Statistics
PubMed Score 2116.66
PubMed score by year
PubTator Score 789.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title