Protein Summary
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]
- ENST00000355237
- ENSP00000347379
- ENSG00000197822
- ENST00000396442
- ENSP00000379719
- ENST00000538151
- ENSP00000445940
- BLCPMG
- PTORCH1
- PPP1R115
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.98 | ||
kinase | 0.96 | ||
PubMedID | 0.92 | ||
chemical | 0.85 | ||
biological term | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2116.66 (req: < 5)
Gene RIFs: 126 (req: <= 3)
Antibodies: 439 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2116.66 (req: >= 5)
Gene RIFs: 126 (req: > 3)
Antibodies: 439 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (221)
MFAP4
Novelty: 0.02023782
p_int: 0.999960281
p_ni: 3.3e-8
p_wrong: 0.000039686
Score: 0.297
Data Source: BioPlex,STRINGDB
PLA2G16
Novelty: 0.02310886
p_int: 0.998688483
p_ni: 0.001311514
p_wrong: 3e-9
Data Source: BioPlex
CTAGE5
Novelty: 0.04516631
p_int: 0.99810321
p_ni: 0.001896789
p_wrong: 1e-9
Data Source: BioPlex
TMEM30B
Novelty: 0.26735006
p_int: 0.998087876
p_ni: 0.001912098
p_wrong: 2.6e-8
Score: 0.293
Data Source: BioPlex,STRINGDB
C4A
Novelty: 0.00062793
p_int: 0.997900461
p_ni: 0.001475763
p_wrong: 0.000623776
Score: 0.155
Data Source: BioPlex,STRINGDB
SDC1
Novelty: 0.00044792
p_int: 0.997355459
p_ni: 0.002644539
p_wrong: 2e-9
Score: 0.267
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (10)
KEGG (5)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Reactome | Apoptotic execution phase | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Apoptotic execution phase | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (1)
Components (10)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | occludin | VGNC:13559 | 741925 | |||||
Macaque | occludin | 700504 | ||||||
Mouse | MGI:106183 | 18260 | ||||||
Rat | RGD:620089 | 83497 | ||||||
Dog | occludin | VGNC:44094 | 403844 | |||||
Publication Statistics
PubMed Score 2116.66
PubMed score by year
PubTator Score 789.65
PubTator score by year
Related Publications
Text Mined References (170)
GeneRif Annotations (126)
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