Tbio STX1A Syntaxin-1A

Protein Summary

Description

Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q16623
• O15447
• O15448
• Q12936
• Q75MD9
• Q7Z5K3
• Q9BPZ6

Gene Name

• STX1A

Ensembl ID

• ENST00000222812
• ENSP00000222812
• ENSG00000106089
• ENST00000395156
• ENSP00000378585

Symbol

• STX1
• STX1
• HPC-1
• P35-1
• SYN1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
gene perturbation	0.9
small molecule perturbation	0.85
biological process	0.84
cellular component	0.75

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Snare Protein / Syntaxin-1a

DTO Classes

Protein / Transporter / Snare Protein / Syntaxin-1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1302.45   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 620   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1302.45   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0