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Tbio
STX1A
Syntaxin-1A

Protein Summary
Description
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222812
  • ENSP00000222812
  • ENSG00000106089
  • ENST00000395156
  • ENSP00000378585

Symbol
  • STX1
  • STX1
  • HPC-1
  • P35-1
  • SYN1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.9
small molecule perturbation
0.85
biological process
0.84
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.92   (req: < 5)
View Publications
Gene RIFs: 58   (req: <= 3)
View Gene RIFs
Antibodies: 620   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 754.92   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (785)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
17 targets
R-HSA-264642
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Disease
1105 targets
R-HSA-1643685
Reactome
Dopamine Neurotransmitter Release Cycle
23 targets
R-HSA-212676
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
17 targets
R-HSA-264642
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Developmental Biology
1055 targets
R-HSA-1266738
Disease
1105 targets
R-HSA-1643685
Dopamine Neurotransmitter Release Cycle
23 targets
R-HSA-212676
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
chloride channel inhibitor activity
Inferred from Direct Assay (IDA)
UniProtKB
kinase binding
Inferred from Physical Interaction (IPI)
UniProtKB
SNAP receptor activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
SNARE binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
ATP-dependent protein binding
Inferred from Electronic Annotation (IEA)
Ensembl
calcium channel inhibitor activity
Inferred from Electronic Annotation (IEA)
Ensembl
calcium-dependent protein binding
Inferred from Electronic Annotation (IEA)
Ensembl
ion channel binding
Inferred from Electronic Annotation (IEA)
Ensembl
myosin head/neck binding
Inferred from Electronic Annotation (IEA)
Ensembl
protein binding, bridging
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (249)
1 – 10 of 249
FAM9C
Tdark
Novelty: 1.42857143
p_int: 0.999999995
p_ni: 4e-9
Data Source: BioPlex
CDR2
Tbio
Novelty: 0.0024428
p_int: 0.999998131
p_ni: 0.000001867
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
OIP5
Tbio
Novelty: 0.04164588
p_int: 0.999989679
p_ni: 0.000010291
p_wrong: 3e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.14861119
p_int: 0.999977008
p_ni: 0.000022978
p_wrong: 1.4e-8
Data Source: BioPlex
STXBP6
Tbio
Novelty: 0.18615646
p_int: 0.999967631
p_ni: 0.000032362
p_wrong: 7e-9
Score: 0.592
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00695477
p_int: 0.999896403
p_ni: 0.000103596
Score: 0.154
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00851075
p_int: 0.999889082
p_ni: 0.000110917
p_wrong: 1e-9
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.04657397
p_int: 0.999061841
p_ni: 0.000754347
p_wrong: 0.000183812
Data Source: BioPlex
STXBP1
Tbio
Novelty: 0.00423336
Score: 0.999
Data Source: Reactome,STRINGDB
SNAP25
Tclin
Novelty: 0.0020914
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  754.92

PubMed score by year
PubTator Score  371.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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