Protein Classes
Protein Summary
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, ...more
- ENST00000222812
- ENSP00000222812
- ENSG00000106089
- ENST00000395156
- ENSP00000378585
- STX1
- STX1
- HPC-1
- P35-1
- SYN1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
gene perturbation | 0.9 | ||
small molecule perturbation | 0.85 | ||
biological process | 0.84 | ||
cellular component | 0.75 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1118.91 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 620 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1118.91 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 620 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 1 | 64.9 | |||||
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | syntaxin 1A | VGNC:4525 | 742605 | |||||
Macaque | syntaxin 1A | 574205 | ||||||
Mouse | MGI:109355 | 20907 | ||||||
Rat | RGD:69430 | 116470 | ||||||
Dog | syntaxin 1A | VGNC:46954 | 100855965 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | syntaxin 1A | |||||
Macaque | syntaxin 1A | |||||
Mouse | ||||||
Rat | ||||||
Dog | syntaxin 1A | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (785)
Reactome (30)
KEGG (4)
PathwayCommons (7)
WikiPathways (744)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 30
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Disease | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Gene Ontology Terms (54)
Functions (13)
Components (23)
Processes (18)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (249)
1 – 10 of 249
FAM9C
Novelty: 0.86727989
p_int: 0.999999995
p_ni: 4e-9
Data Source: BioPlex
CDR2
Novelty: 0.00141419
p_int: 0.999998131
p_ni: 0.000001867
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
OIP5
Novelty: 0.02546471
p_int: 0.999989679
p_ni: 0.000010291
p_wrong: 3e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.11726869
p_int: 0.999977008
p_ni: 0.000022978
p_wrong: 1.4e-8
Data Source: BioPlex
STXBP6
Novelty: 0.13195671
p_int: 0.999967631
p_ni: 0.000032362
p_wrong: 7e-9
Score: 0.592
Data Source: BioPlex,STRINGDB
DGUOK
Family: Kinase
Novelty: 0.00897987
p_int: 0.999896403
p_ni: 0.000103596
Score: 0.154
Data Source: BioPlex,STRINGDB
HAX1
Novelty: 0.00749205
p_int: 0.999889082
p_ni: 0.000110917
p_wrong: 1e-9
Data Source: BioPlex
DNAAF2
Novelty: 0.01254416
p_int: 0.999061841
p_ni: 0.000754347
p_wrong: 0.000183812
Data Source: BioPlex
STXBP1
Novelty: 0.00339098
Score: 0.999
Data Source: Reactome,STRINGDB
SNAP25
Novelty: 0.00148905
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 1118.91
PubMed score by year
PubTator Score 371.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword