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Tbio
STX1A
Syntaxin-1A

Protein Summary
Description
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222812
  • ENSP00000222812
  • ENSG00000106089
  • ENST00000395156
  • ENSP00000378585

Symbol
  • STX1
  • STX1
  • HPC-1
  • P35-1
  • SYN1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.9
small molecule perturbation
0.85
biological process
0.84
cellular component
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1118.91   (req: < 5)
View Publications
Gene RIFs: 58   (req: <= 3)
View Gene RIFs
Antibodies: 620   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1118.91   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
EFO_0004530
1
1
1
64.9
Items per page:
1 – 1 of 1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
EFO_0004530
1
64.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 1A
VGNC:4525
742605
Macaque
syntaxin 1A
574205
Mouse
syntaxin 1A (brain)
MGI:109355
20907
Rat
syntaxin 1A
RGD:69430
116470
Dog
syntaxin 1A
VGNC:46954
100855965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 1A
Macaque
syntaxin 1A
Mouse
syntaxin 1A (brain)
Rat
syntaxin 1A
Dog
syntaxin 1A
Pathways (785)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
17 targets
R-HSA-264642
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Reactome
Developmental Biology
1055 targets
R-HSA-1266738
Reactome
Disease
1105 targets
R-HSA-1643685
Reactome
Dopamine Neurotransmitter Release Cycle
23 targets
R-HSA-212676
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
17 targets
R-HSA-264642
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Developmental Biology
1055 targets
R-HSA-1266738
Disease
1105 targets
R-HSA-1643685
Dopamine Neurotransmitter Release Cycle
23 targets
R-HSA-212676
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
chloride channel inhibitor activity
Inferred from Direct Assay (IDA)
UniProtKB
kinase binding
Inferred from Physical Interaction (IPI)
UniProtKB
SNAP receptor activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
SNARE binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
ATP-dependent protein binding
Inferred from Electronic Annotation (IEA)
Ensembl
calcium channel inhibitor activity
Inferred from Electronic Annotation (IEA)
Ensembl
calcium-dependent protein binding
Inferred from Electronic Annotation (IEA)
Ensembl
ion channel binding
Inferred from Electronic Annotation (IEA)
Ensembl
myosin head/neck binding
Inferred from Electronic Annotation (IEA)
Ensembl
protein binding, bridging
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (249)
1 – 10 of 249
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.999999995
p_ni: 4e-9
Data Source: BioPlex
CDR2
Tbio
Novelty: 0.00141419
p_int: 0.999998131
p_ni: 0.000001867
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
OIP5
Tbio
Novelty: 0.02546471
p_int: 0.999989679
p_ni: 0.000010291
p_wrong: 3e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999977008
p_ni: 0.000022978
p_wrong: 1.4e-8
Data Source: BioPlex
STXBP6
Tbio
Novelty: 0.13195671
p_int: 0.999967631
p_ni: 0.000032362
p_wrong: 7e-9
Score: 0.592
Data Source: BioPlex,STRINGDB
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999896403
p_ni: 0.000103596
Score: 0.154
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.999889082
p_ni: 0.000110917
p_wrong: 1e-9
Data Source: BioPlex
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999061841
p_ni: 0.000754347
p_wrong: 0.000183812
Data Source: BioPlex
STXBP1
Tbio
Novelty: 0.00339098
Score: 0.999
Data Source: Reactome,STRINGDB
SNAP25
Tclin
Novelty: 0.00148905
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1118.91

PubMed score by year
PubTator Score  371.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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