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Tbio
STX1A
Syntaxin-1A

Protein Summary
Description
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222812
  • ENSP00000222812
  • ENSG00000106089
  • ENST00000395156
  • ENSP00000378585

Symbol
  • STX1
  • STX1
  • HPC-1
  • P35-1
  • SYN1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
gene perturbation
0.9
small molecule perturbation
0.85
biological process
0.84
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1141.61   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 620   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1141.61   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 620   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (249)
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999999995
p_ni:  4e-9
Data Source:  BioPlex
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.999998131
p_ni:  0.000001867
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999989679
p_ni:  0.000010291
p_wrong:  3e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999977008
p_ni:  0.000022978
p_wrong:  1.4e-8
Data Source:  BioPlex
STXBP6
Tbio
Novelty:  0.13195671
p_int:  0.999967631
p_ni:  0.000032362
p_wrong:  7e-9
Score:  0.592
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999896403
p_ni:  0.000103596
Score:  0.154
Data Source:  BioPlex,STRINGDB
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.999889082
p_ni:  0.000110917
p_wrong:  1e-9
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.999061841
p_ni:  0.000754347
p_wrong:  0.000183812
Data Source:  BioPlex
STXBP1
Tbio
Novelty:  0.00339098
Score:  0.999
Data Source:  Reactome,STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.999
Data Source:  Reactome,STRINGDB
Pathways (785)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

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Find Similar Targets
Items per page:
1 – 5 of 30
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Dopamine Neurotransmitter Release Cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Cytokine Signaling in Immune system
Developmental Biology
Disease
Dopamine Neurotransmitter Release Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
17
23
10.5
99.9
serum gamma-glutamyl transferase measurement
4
5
4
4.5
98.4
high density lipoprotein cholesterol measurement
6
7
10
98.1
testosterone measurement
4
4
4
94.7
BMI-adjusted waist-hip ratio
6
6
10
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
23
10.5
99.9
serum gamma-glutamyl transferase measurement
4
4.5
98.4
high density lipoprotein cholesterol measurement
10
98.1
testosterone measurement
4
94.7
BMI-adjusted waist-hip ratio
10
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 1A
VGNC:4525
742605
Macaque
syntaxin 1A
574205
Mouse
MGI:109355
20907
Rat
RGD:69430
116470
Dog
syntaxin 1A
VGNC:46954
100855965
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 1A
Macaque
syntaxin 1A
Mouse
Rat
Dog
syntaxin 1A
Publication Statistics
PubMed Score 1141.61
PubMed score by year
PubTator Score 371.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title