Protein Classes
Protein Summary
Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, ...more
- ENST00000222812
- ENSP00000222812
- ENSG00000106089
- ENST00000395156
- ENSP00000378585
- STX1
- STX1
- HPC-1
- P35-1
- SYN1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.91 | ||
gene perturbation | 0.9 | ||
small molecule perturbation | 0.85 | ||
biological process | 0.84 | ||
cellular component | 0.75 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 754.92 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 620 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 754.92 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 620 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (785)
Reactome (30)
KEGG (4)
PathwayCommons (7)
WikiPathways (744)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 30
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Developmental Biology | ||||
Reactome | Disease | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Cytokine Signaling in Immune system | ||||
Developmental Biology | ||||
Disease | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Gene Ontology Terms (54)
Functions (13)
Components (23)
Processes (18)
Items per page:
10
1 – 10 of 13
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (249)
1 – 10 of 249
FAM9C
Novelty: 1.42857143
p_int: 0.999999995
p_ni: 4e-9
Data Source: BioPlex
CDR2
Novelty: 0.0024428
p_int: 0.999998131
p_ni: 0.000001867
p_wrong: 1e-9
Score: 0.237
Data Source: BioPlex,STRINGDB
OIP5
Novelty: 0.04164588
p_int: 0.999989679
p_ni: 0.000010291
p_wrong: 3e-8
Score: 0.193
Data Source: BioPlex,STRINGDB
NUFIP1
Novelty: 0.14861119
p_int: 0.999977008
p_ni: 0.000022978
p_wrong: 1.4e-8
Data Source: BioPlex
STXBP6
Novelty: 0.18615646
p_int: 0.999967631
p_ni: 0.000032362
p_wrong: 7e-9
Score: 0.592
Data Source: BioPlex,STRINGDB
DGUOK
Family: Kinase
Novelty: 0.00695477
p_int: 0.999896403
p_ni: 0.000103596
Score: 0.154
Data Source: BioPlex,STRINGDB
HAX1
Novelty: 0.00851075
p_int: 0.999889082
p_ni: 0.000110917
p_wrong: 1e-9
Data Source: BioPlex
DNAAF2
Novelty: 0.04657397
p_int: 0.999061841
p_ni: 0.000754347
p_wrong: 0.000183812
Data Source: BioPlex
STXBP1
Novelty: 0.00423336
Score: 0.999
Data Source: Reactome,STRINGDB
SNAP25
Novelty: 0.0020914
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 754.92
PubMed score by year
PubTator Score 371.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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