Tchem NFE2 Transcription factor NF-E2 45 kDa subunit

Protein Summary

Description

Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron.

Uniprot Accession IDs

• Q16621
• Q07720
• Q6ICV9

Gene Name

• NFE2

Ensembl ID

• ENST00000312156
• ENSP00000312436
• ENSG00000123405
• ENST00000435572
• ENSP00000397185
• ENST00000540264
• ENSP00000439120
• ENST00000553070
• ENSP00000447558

Symbol

• p45
• NF-E2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
biological process	0.88
histone modification site profile	0.71
transcription factor	0.66
virus perturbation	0.64

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Factor Nf-e2 45 Kda Subunit

Protein / Nucleic Acid Binding / Transcription Factor Nf-e2 45 Kda Subunit

Protein / Hydrolase / Transcription Factor Nf-e2 45 Kda Subunit

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Transcription Factor Nf-e2 45 Kda Subunit

DTO Classes

Protein / Enzyme / Hydrolase / Transcription Factor Nf-e2 45 Kda Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.66   (req: < 5)

Gene RIFs: 43   (req: <= 3)

Antibodies: 136   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.66   (req: >= 5)

Gene RIFs: 43   (req: > 3)

Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0