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Tclin
NTRK2
BDNF/NT-3 growth factors receptor

Protein Summary
Description
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277120
  • ENSP00000277120
  • ENSG00000148053
  • ENST00000304053
  • ENSP00000306167
  • ENST00000323115
  • ENSP00000314586
  • ENST00000359847
  • ENSP00000352906
  • ENST00000376208
  • ENSP00000365381
  • ENST00000376213
  • ENSP00000365386
  • ENST00000376214
  • ENSP00000365387
  • ENST00000395882
  • ENSP00000379221

Symbol
  • TRKB
  • OBHD
  • TRKB
  • trk-B
  • EIEE58
  • GP145-TrkB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
biological term
0.97
PubMedID
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.28   (req: < 5)
Gene RIFs: 233   (req: <= 3)
Antibodies: 1219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1788.28   (req: >= 5)
Gene RIFs: 233   (req: > 3)
Antibodies: 1219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 184
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6