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Tclin
NTRK2
BDNF/NT-3 growth factors receptor

Protein Summary
Description
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277120
  • ENSP00000277120
  • ENSG00000148053
  • ENST00000304053
  • ENSP00000306167
  • ENST00000323115
  • ENSP00000314586
  • ENST00000359847
  • ENSP00000352906
  • ENST00000376208
  • ENSP00000365381
  • ENST00000376213
  • ENSP00000365386
  • ENST00000376214
  • ENSP00000365387
  • ENST00000395882
  • ENSP00000379221

Symbol
  • TRKB
  • OBHD
  • TRKB
  • trk-B
  • EIEE58
  • GP145-TrkB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
biological term
0.97
PubMedID
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1591.9   (req: < 5)
Gene RIFs: 233   (req: <= 3)
Antibodies: 1219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1591.9   (req: >= 5)
Gene RIFs: 233   (req: > 3)
Antibodies: 1219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 80
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5
Active Ligands (80)
1 – 10 of 80
CHEMBL388978
chemical structure image
CHEMBL603469
chemical structure image
CHEMBL1230609
chemical structure image
CHEMBL1822792
chemical structure image
CHEMBL3128069
chemical structure image
CHEMBL2010872
chemical structure image
DDR1/2 inhibitor 5n
chemical structure image
RIPK1 inhibitor 22b
chemical structure image
CHEMBL3673452
chemical structure image
CHEMBL1980995
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
70.4
mathematical ability
2
1
2
69.5
self reported educational attainment
1
1
1
60
1
1
1
48.9
comparative body size at age 10, self-reported
1
1
1
15.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
70.4
mathematical ability
2
69.5
self reported educational attainment
1
60
1
48.9
comparative body size at age 10, self-reported
1
15.3
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (54)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Activated NTRK2 signals through FRS2 and FRS3
Reactome
Activated NTRK2 signals through FYN
Reactome
Activated NTRK2 signals through PI3K
Reactome
Activated NTRK2 signals through PLCG1
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Activated NTRK2 signals through FRS2 and FRS3
Activated NTRK2 signals through FYN
Activated NTRK2 signals through PI3K
Activated NTRK2 signals through PLCG1
Gene Ontology Terms (67)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (357)
1 – 10 of 357
NTF4
Tbio
Novelty: 0.00192875
Score: 0.999
Data Source: Reactome,STRINGDB
BDNF
Tbio
Novelty: 0.00006891
Score: 0.998
Data Source: Reactome,STRINGDB
FRS2
Tbio
Novelty: 0.00654052
Score: 0.998
Data Source: Reactome,STRINGDB
NTF3
Tbio
Novelty: 0.00089023
Score: 0.997
Data Source: Reactome,STRINGDB
NGF
Tchem
Novelty: 0.00008139
Score: 0.992
Data Source: STRINGDB
NGFR
Tclin
Novelty: 0.00072052
Score: 0.992
Data Source: STRINGDB
SHC1
Tchem
Novelty: 0.00083615
Score: 0.989
Data Source: Reactome,STRINGDB
SHC2
Tbio
Novelty: 0.00219395
Score: 0.988
Data Source: STRINGDB
SHC3
Tbio
Novelty: 0.03638847
Score: 0.987
Data Source: STRINGDB
GRIN2B
Tclin
Family: IC
Novelty: 0.00035058
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1591.90

PubMed score by year
PubTator Score  680.64

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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