Tbio CTF1 Cardiotrophin-1

Protein Summary

Description

Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Accession IDs

• Q16619
• A8MVX4
• Q5U5Y7
• CT-1

Gene Name

• CTF1

Ensembl ID

• ENST00000279804
• ENSP00000279804
• ENSG00000150281
• ENST00000395019
• ENSP00000378465

Symbol

• CT1
• CT-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.69
disease perturbation	0.68
transcription factor	0.67
transcription factor binding site profile	0.62
biological process	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.22   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 467   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 338.22   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 467   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0