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Tbio
AANAT
Serotonin N-acetyltransferase

Protein Summary
Description
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250615
  • ENSP00000250615
  • ENSG00000129673
  • ENST00000392492
  • ENSP00000376282

Symbol
  • SNAT
  • DSPS
  • SNAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.87
biological process
0.73
cell type or tissue
0.61
disease perturbation
0.56
transcription factor
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.06   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 254.06   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
67.3
reticulocyte count
3
1
3
54.4
reticulocyte measurement
2
2
2
40.3
mean reticulocyte volume
1
1
1
8.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
67.3
reticulocyte count
3
54.4
reticulocyte measurement
2
40.3
mean reticulocyte volume
1
8.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aralkylamine N-acetyltransferase
VGNC:6317
503504
Macaque
aralkylamine N-acetyltransferase
706924
Mouse
MGI:1328365
11298
Rat
RGD:2006
25120
Dog
aralkylamine N-acetyltransferase
VGNC:37413
483331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aralkylamine N-acetyltransferase
Macaque
aralkylamine N-acetyltransferase
Mouse
Rat
Dog
aralkylamine N-acetyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16613-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Serotonin and melatonin biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Serotonin and melatonin biosynthesis
Protein-Protein Interactions (102)
1 – 10 of 102
ASMT
Tbio
Family: Enzyme
Novelty: 0.00251977
Score: 0.992
Data Source: STRINGDB
DDC
Tclin
Family: Enzyme
Novelty: 0.0012284
Score: 0.957
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.937
Data Source: STRINGDB
YWHAZ
Tbio
Novelty: 0.00210582
Score: 0.936
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.931
Data Source: STRINGDB
IDO1
Tchem
Family: Enzyme
Novelty: 0.00131229
Score: 0.913
Data Source: STRINGDB
IDO2
Tchem
Family: Enzyme
Novelty: 0.01141558
Score: 0.906
Data Source: STRINGDB
INMT
Tchem
Family: Enzyme
Novelty: 0.01771517
Score: 0.9
Data Source: STRINGDB
SLC38A2
Tbio
Family: Transporter
Novelty: 0.00808235
Score: 0.777
Data Source: STRINGDB
MTNR1A
Tclin
Family: GPCR
Novelty: 0.01100617
Score: 0.77
Data Source: STRINGDB
Publication Statistics
PubMed Score  254.06

PubMed score by year
PubTator Score  193.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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