AANAT
Serotonin N-acetyltransferase
Protein Summary
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- ENST00000250615
- ENSP00000250615
- ENSG00000129673
- ENST00000392492
- ENSP00000376282
- SNAT
- DSPS
- SNAT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.87 | ||
biological process | 0.73 | ||
cell type or tissue | 0.61 | ||
disease perturbation | 0.56 | ||
transcription factor | 0.55 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 254.06 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 262 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 254.06 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 262 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 67.3 | |||||
reticulocyte count | 3 | 1 | 3 | 54.4 | |||||
reticulocyte measurement | 2 | 2 | 2 | 40.3 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 8.5 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 67.3 | |||||
reticulocyte count | 3 | 54.4 | |||||
reticulocyte measurement | 2 | 40.3 | |||||
mean reticulocyte volume | 1 | 8.5 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | aralkylamine N-acetyltransferase | VGNC:6317 | 503504 | |||||
Macaque | aralkylamine N-acetyltransferase | 706924 | ||||||
Mouse | MGI:1328365 | 11298 | ||||||
Rat | RGD:2006 | 25120 | ||||||
Dog | aralkylamine N-acetyltransferase | VGNC:37413 | 483331 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | aralkylamine N-acetyltransferase | |||||
Macaque | aralkylamine N-acetyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | aralkylamine N-acetyltransferase | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (13)
Reactome (4)
KEGG (2)
PathwayCommons (2)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Reactome | Serotonin and melatonin biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Serotonin and melatonin biosynthesis | ||||
Gene Ontology Terms (20)
Functions (3)
Components (3)
Processes (14)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (102)
1 – 10 of 102
ASMT
Family: Enzyme
Novelty: 0.00251977
Score: 0.992
Data Source: STRINGDB
DDC
Family: Enzyme
Novelty: 0.0012284
Score: 0.957
Data Source: STRINGDB
MAOA
Family: Enzyme
Novelty: 0.00031037
Score: 0.937
Data Source: STRINGDB
YWHAZ
Novelty: 0.00210582
Score: 0.936
Data Source: STRINGDB
MAOB
Family: Enzyme
Novelty: 0.00030366
Score: 0.931
Data Source: STRINGDB
IDO1
Family: Enzyme
Novelty: 0.00131229
Score: 0.913
Data Source: STRINGDB
IDO2
Family: Enzyme
Novelty: 0.01141558
Score: 0.906
Data Source: STRINGDB
INMT
Family: Enzyme
Novelty: 0.01771517
Score: 0.9
Data Source: STRINGDB
SLC38A2
Family: Transporter
Novelty: 0.00808235
Score: 0.777
Data Source: STRINGDB
MTNR1A
Family: GPCR
Novelty: 0.01100617
Score: 0.77
Data Source: STRINGDB
Publication Statistics
PubMed Score 254.06
PubMed score by year
PubTator Score 193.91
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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