Tbio BAK1 Bcl-2 homologous antagonist/killer

Protein Summary

Description

Plays a role in the mitochondrial apoptosic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16611
• C0H5Y7
• Q6I9T6
• Q92533

Gene Name

• BAK1

Ensembl ID

• ENST00000374467
• ENSP00000363591
• ENSG00000030110
• ENST00000442998
• ENSP00000391258

Symbol

• BAK
• BCL2L7
• CDN1
• BAK
• CDN1
• BCL2L7
• BAK-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
virus	1
viral protein	0.98
chemical	0.96
cellular component	0.89

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Bcl-2 Homologous Antagonist/killer

DTO Classes

Protein / Signaling / Bcl-2 Homologous Antagonist/killer

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.03   (req: < 5)

Gene RIFs: 226   (req: <= 3)

Antibodies: 681   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.03   (req: >= 5)

Gene RIFs: 226   (req: > 3)

Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 61

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0