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Tbio
ECM1
Extracellular matrix protein 1

Protein Summary
Description
Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity. This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346569
  • ENSP00000271630
  • ENSG00000143369
  • ENST00000369047
  • ENSP00000358043
  • ENST00000369049
  • ENSP00000358045

Symbol
  • URBWD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
gene perturbation
0.84
biological process
0.79
small molecule perturbation
0.79
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.17   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 214.17   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (78)
1 – 10 of 78
ATP23
Tbio
Family:  Enzyme
Novelty:  0.09823059
p_int:  0.999979455
p_ni:  0.000020543
p_wrong:  1e-9
Data Source:  BioPlex
FN1
Tchem
Novelty:  0.00003647
p_int:  0.999959493
p_ni:  0.000040507
Score:  0.479
Data Source:  BioPlex,STRINGDB
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.99985925
p_ni:  0.000140739
p_wrong:  1.1e-8
Data Source:  BioPlex
C22orf39
Tdark
Novelty:  1.13707647
p_int:  0.995790801
p_ni:  7.14e-7
p_wrong:  0.004208484
Data Source:  BioPlex
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.995265195
p_ni:  0.004603918
p_wrong:  0.000130887
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.990855022
p_ni:  0.009144978
Data Source:  BioPlex
HIBADH
Tbio
Family:  Enzyme
Novelty:  0.03861647
p_int:  0.987877665
p_ni:  0.012122331
p_wrong:  4e-9
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.986467502
p_ni:  0.013532498
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.985400741
p_ni:  0.014599254
p_wrong:  6e-9
Data Source:  BioPlex
CFAP298
Tbio
Novelty:  0.1550579
p_int:  0.981310289
p_ni:  0.018689711
Data Source:  BioPlex
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (28)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
2
2
93.4
granulocyte percentage of myeloid white cells
1
2
2
93
monocyte count
4
1
4
88.2
vital capacity
1
1
1
80.3
chronotype measurement
1
1
0
1
79.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
93.4
granulocyte percentage of myeloid white cells
2
93
monocyte count
4
88.2
vital capacity
1
80.3
chronotype measurement
0
1
79.7
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
extracellular matrix protein 1
VGNC:1232
746939
Macaque
extracellular matrix protein 1
707209
Mouse
MGI:103060
13601
Rat
RGD:620357
116662
Horse
extracellular matrix protein 1
VGNC:17409
100054714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
extracellular matrix protein 1
Macaque
extracellular matrix protein 1
Mouse
Rat
Horse
extracellular matrix protein 1
Publication Statistics
PubMed Score 214.17
PubMed score by year
PubTator Score 129.17
PubTator score by year