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Tclin
CALCRL
Calcitonin gene-related peptide type 1 receptor

Protein Summary
Description
Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392370
  • ENSP00000376177
  • ENSG00000064989
  • ENST00000409998
  • ENSP00000386972
  • ENST00000410068
  • ENSP00000387190

Symbol
  • CGRPR
  • CRLR
  • CGRPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
protein domain
0.85
cellular component
0.78
gene perturbation
0.74
biological term
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.61   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.61   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 412
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
70.8
cortical surface area measurement
1
1
0
1
70.1
leukocyte count
1
1
1
26.3
Agents acting on the renin-angiotensin system use measurement
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
70.8
cortical surface area measurement
0
1
70.1
leukocyte count
1
26.3
Agents acting on the renin-angiotensin system use measurement
1
6.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcitonin receptor like receptor
VGNC:117
459810
Macaque
calcitonin receptor like receptor
708187
Mouse
MGI:1926944
54598
Rat
RGD:2255
25029
Dog
calcitonin receptor like receptor
VGNC:38665
488438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcitonin receptor like receptor
Macaque
calcitonin receptor like receptor
Mouse
Rat
Dog
calcitonin receptor like receptor
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16602-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (202)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (147)
1 – 10 of 147
RAMP1
Tclin
Novelty: 0.00831253
p_int: 0.978251144
p_ni: 1.3e-8
p_wrong: 0.021748842
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.999
Data Source: Reactome,STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.996
Data Source: Reactome,STRINGDB
RAMP3
Tclin
Novelty: 0.01616194
Score: 0.996
Data Source: Reactome,STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.995
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.995
Data Source: Reactome,STRINGDB
ADM2
Tbio
Novelty: 0.00245573
Score: 0.981
Data Source: Reactome,STRINGDB
CALCB
Tclin
Novelty: 0.02069808
Score: 0.97
Data Source: Reactome,STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.97
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.61

PubMed score by year
PubTator Score  128.4

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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