FXN
Frataxin, mitochondrial
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
biological term | 0.9 | ||
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.85 | ||
transcription factor perturbation | 0.8 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Mitochondrial iron-sulfur cluster biogenesis | ||||
Reactome | Mitochondrial protein import | ||||
Reactome | Protein localization | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Metabolism | ||||
Mitochondrial iron-sulfur cluster biogenesis | ||||
Mitochondrial protein import | ||||
Protein localization | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
Myopia | 2 | 2 | 0 | 5.3 | 86.1 | ||||
age at onset | 1 | 1 | 0 | 9.5 | 74.2 | ||||
refractive error measurement | 2 | 1 | 2 | 9.5 | 74.2 | ||||
Abnormality of refraction | 1 | 1 | 1 | 27.3 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 8.9 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
Myopia | 0 | 5.3 | 86.1 | ||||
age at onset | 0 | 9.5 | 74.2 | ||||
refractive error measurement | 2 | 9.5 | 74.2 | ||||
Abnormality of refraction | 1 | 27.3 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 8.9 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | frataxin | 699469 | ||||||
Mouse | MGI:1096879 | 14297 | ||||||
Rat | RGD:1565754 | 499335 | ||||||
Dog | frataxin | VGNC:41018 | 609051 | |||||
Horse | frataxin | VGNC:18162 | 100056887 | |||||
PMID | Year | Title |
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