Tbio TAF9 Transcription initiation factor TFIID subunit 9

Protein Summary

Description

Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q16594
• D3DWA3
• Q5U0D1
• Q9BTS1

Gene Name

• TAF9

Ensembl ID

• ENST00000217893
• ENSP00000217893
• ENSG00000273841
• ENST00000328663
• ENSP00000370193
• ENST00000506736
• ENSP00000421873
• ENST00000615404
• ENSP00000478935
• ENSG00000276463
• ENST00000616867
• ENSP00000477750
• ENST00000617893
• ENSP00000477611

Symbol

• TAF2G
• TAFII31
• TAF2G
• TAFII31
• TAFII32
• MGC:5067
• TAFII-31
• TAFII-32
• TAFIID32
• STAF31/32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
hub protein	0.98
biological process	0.97
disease perturbation	0.95
molecular function	0.93

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 9

Protein / Nucleic Acid Binding / Transcription Initiation Factor Tfiid Subunit 9

DTO Classes

Protein / Nucleic Acid Binding / Transcription Initiation Factor Tfiid Subunit 9

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.02   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0