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Tbio
TAF9
Transcription initiation factor TFIID subunit 9

Protein Summary
Description
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217893
  • ENSP00000217893
  • ENSG00000273841
  • ENST00000328663
  • ENSP00000370193
  • ENST00000506736
  • ENSP00000421873
  • ENST00000615404
  • ENSP00000478935
  • ENSG00000276463
  • ENST00000616867
  • ENSP00000477750
  • ENST00000617893
  • ENSP00000477611

Symbol
  • TAF2G
  • TAFII31
  • TAF2G
  • TAFII31
  • TAFII32
  • MGC:5067
  • TAFII-31
  • TAFII-32
  • TAFIID32
  • STAF31/32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
hub protein
0.98
biological process
0.97
disease perturbation
0.95
molecular function
0.93


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
94.3
neutrophil count
3
3
3
94.3
myeloid white cell count
2
2
2
90.1
myeloid white cell count
2
2
2
90.1
leukocyte count
2
2
2
86.1
Items per page:
1 – 5 of 28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
94.3
neutrophil count
3
94.3
myeloid white cell count
2
90.1
myeloid white cell count
2
90.1
leukocyte count
2
86.1
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Rat
RGD:727861
373541
Dog
TATA-box binding protein associated factor 9
VGNC:47090
480815
Cow
TATA-box binding protein associated factor 9
VGNC:35582
532936
Anole lizard
transcription initiation factor TFIID subunit 9
100556467
Species
Name
OMA
EggNOG
Inparanoid
Rat
Dog
TATA-box binding protein associated factor 9
Cow
TATA-box binding protein associated factor 9
Anole lizard
transcription initiation factor TFIID subunit 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16594-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (32)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Disease
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (34)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (103)
1 – 10 of 103
TAF12
Tbio
Novelty:  0.04352637
p_int:  0.999999507
p_ni:  4.93e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
p_int:  0.999998541
p_ni:  0.000001459
Data Source:  BioPlex
SUPT20H
Tbio
Novelty:  0.00625899
p_int:  0.999811771
p_ni:  0.000188229
Score:  0.945
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.855352509
p_ni:  0.1446474
p_wrong:  9.1e-8
Data Source:  BioPlex
TAF6
Tbio
Novelty:  0.04357176
Score:  0.987
Data Source:  STRINGDB
TAF11
Tchem
Novelty:  0.10299251
Score:  0.987
Data Source:  STRINGDB
TAF10
Tbio
Novelty:  0.0276004
Score:  0.987
Data Source:  STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
Score:  0.985
Data Source:  STRINGDB
TAF4
Tbio
Novelty:  0.02101584
Score:  0.984
Data Source:  STRINGDB
SUPT3H
Tbio
Novelty:  0.13202683
Score:  0.984
Data Source:  STRINGDB
Publication Statistics
PubTator Score  25.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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