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Tchem
C3AR1
C3a anaphylatoxin chemotactic receptor

Protein Summary
Description
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307637
  • ENSP00000302079
  • ENSG00000171860

Symbol
  • AZ3B
  • C3R1
  • HNFAG09
  • AZ3B
  • C3AR
  • HNFAG09
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease perturbation
0.83
cell type or tissue
0.77
molecular function
0.76
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.63   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.63   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0