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Tchem
C3AR1
C3a anaphylatoxin chemotactic receptor

Protein Summary
Description
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. C3a is an anaphylatoxin released during activation of the complement system. The protein encoded by this gene is an orphan G protein-coupled receptor for C3a. Binding of C3a by the encoded receptor activates chemotaxis, granule enzyme release, superoxide anion production, and bacterial opsonization. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307637
  • ENSP00000302079
  • ENSG00000171860

Symbol
  • AZ3B
  • C3R1
  • HNFAG09
  • AZ3B
  • C3AR
  • HNFAG09
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
disease perturbation
0.83
cell type or tissue
0.77
molecular function
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.08   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.08   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
27
neutrophil count
1
1
1
19.8
neutrophil percentage of leukocytes
1
1
1
13.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
27
neutrophil count
1
19.8
neutrophil percentage of leukocytes
1
13.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C3a receptor 1
VGNC:5313
466942
Macaque
complement C3a receptor 1
716086
Mouse
MGI:1097680
12267
Rat
RGD:620537
84007
Dog
complement C3a receptor 1
VGNC:38592
486704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C3a receptor 1
Macaque
complement C3a receptor 1
Mouse
Rat
Dog
complement C3a receptor 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16581-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Complement cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Complement cascade
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (537)
1 – 10 of 537
RDH14
Tdark
Family: Enzyme
Novelty: 0.35816611
p_int: 0.999976073
p_ni: 0.000023927
Data Source: BioPlex
PTPN2
Tchem
Family: Enzyme
Novelty: 0.00372891
p_int: 0.999902414
p_ni: 0.000092607
p_wrong: 0.00000498
Data Source: BioPlex
PEX13
Tbio
Novelty: 0.01777214
p_int: 0.999856826
p_ni: 0.000143168
p_wrong: 5e-9
Data Source: BioPlex
VEZT
Tbio
Novelty: 0.06274137
p_int: 0.99966512
p_ni: 0.000334875
p_wrong: 4e-9
Data Source: BioPlex
GOLGA5
Tbio
Novelty: 0.04940885
p_int: 0.999362029
p_ni: 0.000637971
Data Source: BioPlex
ELOVL2
Tbio
Novelty: 0.00665823
p_int: 0.998802469
p_ni: 0.00119165
p_wrong: 0.000005882
Data Source: BioPlex
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
p_int: 0.998587504
p_ni: 0.001412495
Score: 0.91
Data Source: BioPlex,STRINGDB
HACD2
Tbio
Family: Enzyme
Novelty: 0.16943742
p_int: 0.998535049
p_ni: 0.001464951
Data Source: BioPlex
ATP2B3
Tbio
Family: Transporter
Novelty: 0.00901493
p_int: 0.998160555
p_ni: 0.001839445
p_wrong: 1e-9
Data Source: BioPlex
ZDHHC17
Tbio
Family: Enzyme
Novelty: 0.03288707
p_int: 0.998156909
p_ni: 0.001843091
Data Source: BioPlex
Publication Statistics
PubMed Score  226.08

PubMed score by year
PubTator Score  73.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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