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Tchem
SLC18A3
Vesicular acetylcholine transporter

Protein Summary
Description
Involved in acetylcholine transport into synaptic vesicles. This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374115
  • ENSP00000363229
  • ENSG00000187714

Symbol
  • VACHT
  • CMS21
  • VACHT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.69
molecular function
0.56
phenotype
0.54
cell line
0.48
PubMedID
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 726.17   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 167
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
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RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (167)
CHEMBL1645202
Rendered image for CHEMBL1645202
Vesamicol
Rendered image for Vesamicol
aminobenzovesamicol
Rendered image for aminobenzovesamicol
CHEMBL341139
Rendered image for CHEMBL341139
CHEMBL340185
Rendered image for CHEMBL340185
CHEMBL339281
Rendered image for CHEMBL339281
CHEMBL315146
Rendered image for CHEMBL315146
CHEMBL95857
Rendered image for CHEMBL95857
p-fluorobenzyltrozamicol
Rendered image for p-fluorobenzyltrozamicol
CHEMBL87414
Rendered image for CHEMBL87414
Protein-Protein Interactions (256)
SLC32A1
Tchem
Family:  Transporter
Novelty:  0.00237273
Score:  0.975
Data Source:  STRINGDB
SYT2
Tbio
Novelty:  0.00754735
Score:  0.96
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.959
Data Source:  Reactome,STRINGDB
SLC17A7
Tbio
Family:  Transporter
Novelty:  0.00165722
Score:  0.958
Data Source:  STRINGDB
SLC17A6
Tbio
Family:  Transporter
Novelty:  0.00163193
Score:  0.958
Data Source:  STRINGDB
CHAT
Tchem
Family:  Enzyme
Novelty:  0.00033026
Score:  0.956
Data Source:  STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.954
Data Source:  STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.947
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.938
Data Source:  STRINGDB
VAMP2
Tbio
Novelty:  0.00187736
Score:  0.938
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Neuronal System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
86.7
1
1
1
61.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
86.7
1
61.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A3
VGNC:7862
466071
Mouse
MGI:1101061
20508
Dog
solute carrier family 18 member A3
VGNC:46257
486774
Cow
solute carrier family 18 member A3
VGNC:34707
785833
Opossum
solute carrier family 18 member A3
103092068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A3
Mouse
Dog
solute carrier family 18 member A3
Cow
solute carrier family 18 member A3
Opossum
solute carrier family 18 member A3
Publication Statistics
PubMed Score 726.17
PubMed score by year
PubTator Score 134.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title