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Tbio
ACKR1
Atypical chemokine receptor 1

Protein Summary
Description
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent prese ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368121
  • ENSP00000357103
  • ENSG00000213088
  • ENST00000368122
  • ENSP00000357104
  • ENST00000537147
  • ENSP00000441985

Symbol
  • DARC
  • FY
  • GPD
  • FY
  • Dfy
  • GPD
  • DARC
  • GpFy
  • CCBP1
  • CD234
  • WBCQ1
  • DARC/ACKR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.77
phenotype
0.77
trait
0.75
disease
0.68
transcription factor
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.91   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 501   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 645.91   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
CXCL8
Tchem
Novelty:  0.00005958
Score:  0.981
Data Source:  Reactome,STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.918
Data Source:  STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.905
Data Source:  STRINGDB
NTRK1
Tclin
Family:  Kinase
Novelty:  0.00033453
Score:  0.902
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.9
Data Source:  STRINGDB
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
Score:  0.9
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.9
Data Source:  STRINGDB
TNFRSF14
Tbio
Novelty:  0.00345486
Score:  0.838
Data Source:  STRINGDB
NECTIN1
Tbio
Novelty:  0.00348549
Score:  0.835
Data Source:  STRINGDB
CCL2
Tchem
Novelty:  0.00010958
Score:  0.81
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (81)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
7
5
11
15.6
99.2
C-reactive protein measurement
3
11
11
99
neutrophil count
7
5
12
98.6
granulocyte count
2
6
7
98.5
myeloid white cell count
4
3
6
98.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
11
15.6
99.2
C-reactive protein measurement
11
99
neutrophil count
12
98.6
granulocyte count
7
98.5
myeloid white cell count
6
98.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
atypical chemokine receptor 1
VGNC:52914
745985
Macaque
atypical chemokine receptor 1 (Duffy blood group)
719284
Mouse
MGI:1097689
13349
Dog
atypical chemokine receptor 1
VGNC:53112
100856110
Horse
atypical chemokine receptor 1 (Duffy blood group) [Source:HGNC Symbol;Acc:HGNC:4035]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
atypical chemokine receptor 1
Macaque
atypical chemokine receptor 1 (Duffy blood group)
Mouse
Dog
atypical chemokine receptor 1
Horse
atypical chemokine receptor 1 (Duffy blood group) [Source:HGNC Symbol;Acc:HGNC:4035]
Publication Statistics
PubMed Score 645.91
PubMed score by year
PubTator Score 416.60
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title