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Tbio
CAMK4
Calcium/calmodulin-dependent protein kinase type IV

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282356
  • ENSP00000282356
  • ENSG00000152495
  • ENST00000512453
  • ENSP00000422634

Symbol
  • CAMK
  • CAMK-GR
  • CAMKIV
  • caMK
  • CaMKIV
  • CaMK IV
  • CaMK-GR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.96
molecular function
0.96
trait
0.93
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.74   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.74   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
76.9
mathematical ability
2
1
2
66.3
autoimmune thyroid disease
1
1
0
1.1
43.8
monocyte count
1
1
1
37.8
lymphocyte percentage of leukocytes
1
1
1
31
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
76.9
mathematical ability
2
66.3
autoimmune thyroid disease
0
1.1
43.8
monocyte count
1
37.8
lymphocyte percentage of leukocytes
1
31
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (72)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
CaMK IV-mediated phosphorylation of CREB
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
CaM pathway
CaMK IV-mediated phosphorylation of CREB
Protein-Protein Interactions (136)
1 – 10 of 136
GIT1
Tbio
Family: Enzyme
Novelty: 0.01022741
p_int: 0.998429477
p_ni: 0.001570523
Score: 0.82
Data Source: BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty: 0.00919946
p_int: 0.99633262
p_ni: 0.00366738
Score: 0.819
Data Source: BioPlex,STRINGDB
GIT2
Tbio
Family: Enzyme
Novelty: 0.01530665
p_int: 0.98437547
p_ni: 0.015624522
p_wrong: 8e-9
Score: 0.813
Data Source: BioPlex,STRINGDB
ANKRD28
Tbio
Family: Enzyme
Novelty: 0.10895759
p_int: 0.931665338
p_ni: 0.068334662
Score: 0.574
Data Source: BioPlex,STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.898969955
p_ni: 0.101030043
p_wrong: 1e-9
Score: 0.555
Data Source: BioPlex,STRINGDB
ANKRD52
Tbio
Family: Enzyme
Novelty: 0.14147652
p_int: 0.756554392
p_ni: 0.243445608
Score: 0.804
Data Source: BioPlex,STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.992
Data Source: Reactome,STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.964
Data Source: Reactome,STRINGDB
CABIN1
Tbio
Novelty: 0.02528794
Score: 0.964
Data Source: STRINGDB
CAMKK1
Tchem
Family: Kinase
Novelty: 0.06355265
Score: 0.962
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  240.74

PubMed score by year
PubTator Score  129.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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