You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CAMK4
Calcium/calmodulin-dependent protein kinase type IV

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282356
  • ENSP00000282356
  • ENSG00000152495
  • ENST00000512453
  • ENSP00000422634

Symbol
  • CAMK
  • CAMK-GR
  • CAMKIV
  • caMK
  • CaMKIV
  • CaMK IV
  • CaMK-GR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.96
molecular function
0.96
trait
0.93
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.35   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 246.35   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
GIT1
Tbio
Family:  Enzyme
Novelty:  0.01022741
p_int:  0.998429477
p_ni:  0.001570523
Score:  0.82
Data Source:  BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.99633262
p_ni:  0.00366738
Score:  0.819
Data Source:  BioPlex,STRINGDB
GIT2
Tbio
Family:  Enzyme
Novelty:  0.01530665
p_int:  0.98437547
p_ni:  0.015624522
p_wrong:  8e-9
Score:  0.813
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.931665338
p_ni:  0.068334662
Score:  0.574
Data Source:  BioPlex,STRINGDB
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.898969955
p_ni:  0.101030043
p_wrong:  1e-9
Score:  0.555
Data Source:  BioPlex,STRINGDB
ANKRD52
Tbio
Family:  Enzyme
Novelty:  0.14147652
p_int:  0.756554392
p_ni:  0.243445608
Score:  0.804
Data Source:  BioPlex,STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.992
Data Source:  Reactome,STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.964
Data Source:  Reactome,STRINGDB
CABIN1
Tbio
Novelty:  0.02528794
Score:  0.964
Data Source:  STRINGDB
CAMKK1
Tchem
Family:  Kinase
Novelty:  0.06355265
Score:  0.962
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
Pathways (72)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Reactome
Ca-dependent events
Reactome
CaM pathway
Reactome
CaMK IV-mediated phosphorylation of CREB
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ca-dependent events
CaM pathway
CaMK IV-mediated phosphorylation of CREB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
5
0
1.1
97.7
6
2
3
1.1
86.2
lymphocyte count
2
1
2
75.9
chronotype measurement
2
1
1
1
69.4
lymphocyte percentage of leukocytes
1
1
1
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97.7
3
1.1
86.2
lymphocyte count
2
75.9
chronotype measurement
1
1
69.4
lymphocyte percentage of leukocytes
1
60.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase IV
VGNC:11867
461992
Macaque
calcium/calmodulin dependent protein kinase IV
712322
Mouse
MGI:88258
12326
Rat
RGD:2264
25050
Dog
calcium/calmodulin dependent protein kinase IV
VGNC:53157
100684140
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium/calmodulin dependent protein kinase IV
Macaque
calcium/calmodulin dependent protein kinase IV
Mouse
Rat
Dog
calcium/calmodulin dependent protein kinase IV
Publication Statistics
PubMed Score 246.35
PubMed score by year
PubTator Score 129.89
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title