You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CAMK4
Calcium/calmodulin-dependent protein kinase type IV

Protein Summary
Description
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282356
  • ENSP00000282356
  • ENSG00000152495
  • ENST00000512453
  • ENSP00000422634

Symbol
  • CAMK
  • CAMK-GR
  • CAMKIV
  • caMK
  • CaMKIV
  • CaMK IV
  • CaMK-GR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
biological process
0.96
molecular function
0.96
trait
0.93
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.11   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 550   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.11   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 550   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0