Tbio KCNMB1 Calcium-activated potassium channel subunit beta-1

Protein Summary

Description

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16558
• O00707
• O00708
• P78475
• Q53YR0
• Q8TAX3
• Q93005

Gene Name

• KCNMB1

Ensembl ID

• ENST00000274629
• ENSP00000274629
• ENSG00000145936
• ENST00000521859
• ENSP00000427940

Symbol

• hbeta1
• BKbeta1
• SLO-BETA
• hslo-beta
• K(VCA)beta
• slo-beta-1
• k(VCA)beta-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.81
gene perturbation	0.73
cell type or tissue	0.66
tissue sample	0.61
biological term	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Potassium Channel / Calcium-activated Potassium Channel Subunit Beta-1

Protein / Transporter / Ion Channel / Potassium Channel / Voltage-gated Potassium Channel / Calcium-activated Potassium Channel Subunit Beta-1

DTO Classes

Protein / Ion Channel / Calcium-activated Potassium Channel Auxiliary Subunit Slowpoke- (Slo) Family / Kcnmb/kcnmb1 Subfamily / Calcium-activated Potassium Channel Subunit Beta-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 144.51   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0