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Tbio
DPYSL2
Dihydropyrimidinase-related protein 2

Protein Summary
Description
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311151
  • ENSP00000309539
  • ENSG00000092964
  • ENST00000523027
  • ENSP00000431117

Symbol
  • CRMP2
  • ULIP2
  • DRP2
  • N2A3
  • CRMP2
  • DRP-2
  • ULIP2
  • CRMP-2
  • DHPRP2
  • ULIP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.96
PubMedID
0.94
virus perturbation
0.94
kinase perturbation
0.93
cellular component
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.37   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 328.37   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
32.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
32.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 2
VGNC:6565
464070
Macaque
dihydropyrimidinase like 2
712368
Mouse
MGI:1349763
12934
Rat
RGD:2517
25416
Dog
dihydropyrimidinase like 2
VGNC:40083
486107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydropyrimidinase like 2
Macaque
dihydropyrimidinase like 2
Mouse
Rat
Dog
dihydropyrimidinase like 2
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (538)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
L1CAM interactions
Reactome
Recycling pathway of L1
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
L1CAM interactions
Recycling pathway of L1
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (125)
1 – 10 of 125
DPYSL3
Tbio
Family: Enzyme
Novelty: 0.01284077
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
DPYSL5
Tbio
Family: Enzyme
Novelty: 0.0052536
p_int: 0.999995026
p_ni: 0.000004974
Score: 0.986
Data Source: BioPlex,STRINGDB
DPYS
Tbio
Family: Enzyme
Novelty: 0.01272377
p_int: 0.999950103
p_ni: 0.000049897
Score: 0.853
Data Source: BioPlex,STRINGDB
DPYSL4
Tbio
Family: Enzyme
Novelty: 0.0449179
p_int: 0.999387081
p_ni: 0.000612919
Score: 0.916
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.996383013
p_ni: 0.003616987
Data Source: BioPlex
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.995993515
p_ni: 0.004006485
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.993273609
p_ni: 0.006726391
Data Source: BioPlex
LGALS7
Tbio
Novelty: 0.00753996
p_int: 0.991011856
p_ni: 0.008988144
Score: 0.19
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.988875595
p_ni: 0.011124405
Score: 0.177
Data Source: BioPlex,STRINGDB
SPSB3
Tdark
Novelty: 0.07215887
p_int: 0.98650005
p_ni: 0.01349995
Data Source: BioPlex
Publication Statistics
PubMed Score  328.37

PubMed score by year
PubTator Score  119.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer