Tbio DPYSL2 Dihydropyrimidinase-related protein 2

Protein Summary

Description

Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. This gene encodes a member of the collapsin response mediator protein family. Collapsin response mediator proteins form homo- and hetero-tetramers and facilitate neuron guidance, growth and polarity. The encoded protein promotes microtubule assembly and is required for Sema3A-mediated growth cone collapse, and also plays a role in synaptic signaling through interactions with calcium channels. This gene has been implicated in multiple neurological disorders, and hyperphosphorylation of the encoded protein may play a key role in the development of Alzheimer's disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q16555
• A8K5H2
• B4DR31
• D3DSS7
• O00424
• DRP-2

Gene Name

• DPYSL2

Ensembl ID

• ENST00000311151
• ENSP00000309539
• ENSG00000092964
• ENST00000523027
• ENSP00000431117

Symbol

• CRMP2
• ULIP2
• DRP2
• N2A3
• CRMP2
• DRP-2
• ULIP2
• CRMP-2
• DHPRP2
• ULIP-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.96
PubMedID	0.94
virus perturbation	0.94
kinase perturbation	0.93
cellular component	0.85

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dihydropyrimidinase-related Protein 2

Protein / ... / Metalloprotease / Dihydropyrimidinase-related Protein 2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Dihydropyrimidinase-related Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.39   (req: < 5)

Gene RIFs: 68   (req: <= 3)

Antibodies: 534   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.39   (req: >= 5)

Gene RIFs: 68   (req: > 3)

Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0