Protein Summary
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
- ENST00000340057
- ENSP00000344192
- ENSG00000112115
- ENST00000648244
- ENSP00000497968
- CTLA8
- IL17
- IL17
- CTLA8
- IL-17
- CTLA-8
- IL-17A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.8 | ||
chemical | 0.79 | ||
cell type or tissue | 0.76 | ||
gene perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10220.53 (req: < 5)
Gene RIFs: 1104 (req: <= 3)
Antibodies: 1677 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10220.53 (req: >= 5)
Gene RIFs: 1104 (req: > 3)
Antibodies: 1677 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (497)
IL2
Novelty: 0.00003129
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
DPP8
Family: Enzyme
Novelty: 0.00678793
p_int: 0.998987533
p_ni: 0.001012445
p_wrong: 2.3e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
LONP2
Family: Enzyme
Novelty: 0.04499043
p_int: 0.997777279
p_ni: 0.002222713
p_wrong: 8e-9
Score: 0.28
Data Source: BioPlex,STRINGDB
TXNDC15
Novelty: 0.23488442
p_int: 0.97058669
p_ni: 0.029413309
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
IL17RA
Novelty: 0.00416706
p_int: 0.939158729
p_ni: 0.060841271
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (5)
KEGG (5)
PathwayCommons (9)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-17 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-17 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (2)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
DNA methylation | 1 | 1 | 1 | 31.1 | |||||
response to gemcitabine | 1 | 1 | 0 | 3.3 | 17.8 | ||||
1 | 1 | 0 | 3.3 | 17.8 | |||||
overall survival | 1 | 1 | 0 | 3.3 | 17.8 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
DNA methylation | 1 | 31.1 | |||||
response to gemcitabine | 0 | 3.3 | 17.8 | ||||
0 | 3.3 | 17.8 | |||||
overall survival | 0 | 3.3 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interleukin 17A | VGNC:3123 | 472029 | |||||
Macaque | interleukin 17A | 708123 | ||||||
Mouse | MGI:107364 | 16171 | ||||||
Rat | RGD:2888 | 301289 | ||||||
Dog | interleukin 17A | VGNC:41942 | 481837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interleukin 17A | |||||
Macaque | interleukin 17A | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 17A | |||||
Publication Statistics
PubMed Score 10220.53
PubMed score by year
PubTator Score 3470.88
PubTator score by year
Related Publications
Text Mined References (1137)
GeneRif Annotations (1104)
Items per page:
0 of 0
PMID | Year | Title |
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