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Tclin
IL17A
Interleukin-17A

Protein Summary
Description
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340057
  • ENSP00000344192
  • ENSG00000112115
  • ENST00000648244
  • ENSP00000497968

Symbol
  • CTLA8
  • IL17
  • IL17
  • CTLA8
  • IL-17
  • CTLA-8
  • IL-17A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.8
chemical
0.79
cell type or tissue
0.76
gene perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10220.53   (req: < 5)
Gene RIFs: 1104   (req: <= 3)
Antibodies: 1677   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10220.53   (req: >= 5)
Gene RIFs: 1104   (req: > 3)
Antibodies: 1677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DNA methylation
1
1
1
31.1
response to gemcitabine
1
1
0
3.3
17.8
1
1
0
3.3
17.8
overall survival
1
1
0
3.3
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
DNA methylation
1
31.1
response to gemcitabine
0
3.3
17.8
0
3.3
17.8
overall survival
0
3.3
17.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 17A
VGNC:3123
472029
Macaque
interleukin 17A
708123
Mouse
MGI:107364
16171
Rat
RGD:2888
301289
Dog
interleukin 17A
VGNC:41942
481837
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 17A
Macaque
interleukin 17A
Mouse
Rat
Dog
interleukin 17A
Protein Structure (12 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (497)
1 – 10 of 497
IL2
Tchem
Novelty:  0.00003129
p_int:  0.999999999
p_ni:  1e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
DPP8
Tchem
Family:  Enzyme
Novelty:  0.00678793
p_int:  0.998987533
p_ni:  0.001012445
p_wrong:  2.3e-8
Score:  0.241
Data Source:  BioPlex,STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
p_int:  0.997777279
p_ni:  0.002222713
p_wrong:  8e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
TXNDC15
Tdark
Novelty:  0.23488442
p_int:  0.97058669
p_ni:  0.029413309
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.939158729
p_ni:  0.060841271
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.993
Data Source:  STRINGDB
IL17F
Tbio
Novelty:  0.00223549
Score:  0.986
Data Source:  Reactome,STRINGDB
IL17RC
Tclin
Novelty:  0.01844832
Score:  0.985
Data Source:  Reactome,STRINGDB
STAT6
Tchem
Family:  TF
Novelty:  0.00096732
Score:  0.982
Data Source:  STRINGDB
IL6
Tclin
Novelty:  0.00001819
Score:  0.971
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10220.53

PubMed score by year
PubTator Score  3470.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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