Protein Summary
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
- ENST00000340057
- ENSP00000344192
- ENSG00000112115
- ENST00000648244
- ENSP00000497968
- CTLA8
- IL17
- IL17
- CTLA8
- IL-17
- CTLA-8
- IL-17A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
biological process | 0.8 | ||
chemical | 0.79 | ||
cell type or tissue | 0.76 | ||
gene perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10220.53 (req: < 5)
Gene RIFs: 1104 (req: <= 3)
Antibodies: 1677 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10220.53 (req: >= 5)
Gene RIFs: 1104 (req: > 3)
Antibodies: 1677 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (0)
Protein-Protein Interactions (497)
IL2
Novelty: 0.00003129
p_int: 0.999999999
p_ni: 1e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
DPP8
Family: Enzyme
Novelty: 0.00678793
p_int: 0.998987533
p_ni: 0.001012445
p_wrong: 2.3e-8
Score: 0.241
Data Source: BioPlex,STRINGDB
LONP2
Family: Enzyme
Novelty: 0.04499043
p_int: 0.997777279
p_ni: 0.002222713
p_wrong: 8e-9
Score: 0.28
Data Source: BioPlex,STRINGDB
TXNDC15
Novelty: 0.23488442
p_int: 0.97058669
p_ni: 0.029413309
p_wrong: 1e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
IL17RA
Novelty: 0.00416706
p_int: 0.939158729
p_ni: 0.060841271
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (24)
Reactome (5)
KEGG (5)
PathwayCommons (9)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-17 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-17 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (1)
Components (2)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
DNA methylation | 1 | 1 | 1 | 31.1 | |||||
response to gemcitabine | 1 | 1 | 0 | 3.3 | 17.8 | ||||
1 | 1 | 0 | 3.3 | 17.8 | |||||
overall survival | 1 | 1 | 0 | 3.3 | 17.8 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
DNA methylation | 1 | 31.1 | |||||
response to gemcitabine | 0 | 3.3 | 17.8 | ||||
0 | 3.3 | 17.8 | |||||
overall survival | 0 | 3.3 | 17.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | interleukin 17A | VGNC:3123 | 472029 | |||||
Macaque | interleukin 17A | 708123 | ||||||
Mouse | MGI:107364 | 16171 | ||||||
Rat | RGD:2888 | 301289 | ||||||
Dog | interleukin 17A | VGNC:41942 | 481837 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | interleukin 17A | |||||
Macaque | interleukin 17A | |||||
Mouse | ||||||
Rat | ||||||
Dog | interleukin 17A | |||||
Publication Statistics
PubMed Score 10220.53
PubMed score by year
PubTator Score 3470.88
PubTator score by year
Related Publications
Text Mined References (1137)
GeneRif Annotations (1104)
Items per page:
0 of 0
PMID | Year | Title |
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