Tclin IL17A Interleukin-17A

Protein Summary

Description

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q16552
• Q5T2P0
• IL-17

Gene Name

• IL17A

Ensembl ID

• ENST00000340057
• ENSP00000344192
• ENSG00000112115
• ENST00000648244
• ENSP00000497968

Symbol

• CTLA8
• IL17
• IL17
• CTLA8
• IL-17
• CTLA-8
• IL-17A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
biological process	0.8
chemical	0.79
cell type or tissue	0.76
gene perturbation	0.76

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10220.53   (req: < 5)

Gene RIFs: 1104   (req: <= 3)

Antibodies: 1677   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10220.53   (req: >= 5)

Gene RIFs: 1104   (req: > 3)

Antibodies: 1677   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

secukinumab

IL17ATclin

ANTIBODY BINDING :

ixekizumab

IL17ATclin

ANTIBODY BINDING :

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
DNA methylation	GO_0006306	1	1	1		31.1
response to gemcitabine	GO_0036272	1	1	0	3.3	17.8
pancreatic carcinoma	EFO_0002618	1	1	0	3.3	17.8
overall survival	EFO_0000638	1	1	0	3.3	17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
DNA methylation	GO_0006306	1		31.1
response to gemcitabine	GO_0036272	0	3.3	17.8
pancreatic carcinoma	EFO_0002618	0	3.3	17.8
overall survival	EFO_0000638	0	3.3	17.8

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	interleukin 17A	VGNC:3123	472029
Macaque	interleukin 17A		708123
Mouse	interleukin 17A	MGI:107364	16171
Rat	interleukin 17A	RGD:2888	301289
Dog	interleukin 17A	VGNC:41942	481837

Species	Name	OMA	EggNOG	Inparanoid
Chimp	interleukin 17A
Macaque	interleukin 17A
Mouse	interleukin 17A
Rat	interleukin 17A
Dog	interleukin 17A

Protein Structure (12 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q16552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 12

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (24)

Reactome (5)

KEGG (5)

PathwayCommons (9)

WikiPathways (5)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Interleukin-17 signaling	71 targets	R-HSA-448424
Reactome	Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807
Reactome	Signaling by Interleukins	619 targets	R-HSA-449147

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
Interleukin-17 signaling	71 targets	R-HSA-448424
Interleukin-4 and Interleukin-13 signaling	111 targets	R-HSA-6785807
Signaling by Interleukins	619 targets	R-HSA-449147

Gene Ontology Terms (14)

Functions (1)

Components (2)

Processes (11)

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Items per page:

10

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GO Term	Evidence	Assigned by
cytokine activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (497)

Explore Interacting Targets

1 – 10 of 497

• See Interactions on String-DB

IL2

Tchem

Novelty:  0.00003129

p_int:  0.999999999

p_ni:  1e-9

Score:  0.982

Data Source:  BioPlex,STRINGDB

DPP8

Tchem

Family:  Enzyme

Novelty:  0.00678793

p_int:  0.998987533

p_ni:  0.001012445

p_wrong:  2.3e-8

Score:  0.241

Data Source:  BioPlex,STRINGDB

LONP2

Tbio

Family:  Enzyme

Novelty:  0.04499043

p_int:  0.997777279

p_ni:  0.002222713

p_wrong:  8e-9

Score:  0.28

Data Source:  BioPlex,STRINGDB

TXNDC15

Tdark

Novelty:  0.23488442

p_int:  0.97058669

p_ni:  0.029413309

p_wrong:  1e-9

Score:  0.177

Data Source:  BioPlex,STRINGDB

IL17RA

Tclin

Novelty:  0.00416706

p_int:  0.939158729

p_ni:  0.060841271

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

STAT3

Tchem

Family:  TF

Novelty:  0.00011808

Score:  0.993

Data Source:  STRINGDB

IL17F

Tbio

Novelty:  0.00223549

Score:  0.986

Data Source:  Reactome,STRINGDB

IL17RC

Tclin

Novelty:  0.01844832

Score:  0.985

Data Source:  Reactome,STRINGDB

STAT6

Tchem

Family:  TF

Novelty:  0.00096732

Score:  0.982

Data Source:  STRINGDB

IL6

Tclin

Novelty:  0.00001819

Score:  0.971

Data Source:  STRINGDB

Publication Statistics

PubMed Score  10220.53

PubMed score by year

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PubTator Score  3470.88

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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GWAS Trait Find Similar Targets

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DNA methylation
overall survival
pancreatic carcinoma
response to gemcitabine

MGI Phenotype Find Similar Targets

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cellular phenotype
digestive/alimentary phenotype
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hematopoietic system phenotype
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immune system phenotype
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respiratory system phenotype